MC-Val-Cit-PABC-PNP

MC-Val-Cit-PABC-PNP 是一种组织蛋白酶可裂解的 ADC 肽接头,可用于合成抗体偶联药物。

CAS号

159857-81-5

分子式

C35H43N7O11

主要靶点

AChR|Others

仅限科研使用

Cat No : CM00903

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Synonyms

Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate|马来酰亚胺基己酰-L-缬氨酸-L-瓜氨酸对氨基苄醇 对硝基苯基碳酸脂



产品信息

MC-Val-Cit-PABC-PNP, also known as Mc-Val-Cit-PABC-PNP, is a cathepsin cleavable ADC peptide linker. For example, FDA approved drug, brentuximab vedotin, adopts this linker. Protein- and peptide-drug conjugates hold a promising stance in the delivery of therapeutic agents by providing distinct advantage of improving therapeutic potential of drugs. Use of specialized linkers makes them unique in their in vivo therapeutic application by providing target tissue-specific release of drug.

CAS号 159857-81-5
分子式 C35H43N7O11
主要靶点 AChR|Others
主要通路 神经科学|其他
分子量 737.77
纯度 97.20%, 此纯度可做参考,具体纯度与批次有关系,可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate|马来酰亚胺基己酰-L-缬氨酸-L-瓜氨酸对氨基苄醇 对硝基苯基碳酸脂

溶解度

DMSO:37 mg/mL

参考文献

1.Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2