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Maytansine

Maytansine (NSC-153858) 是从变叶美登木中分离的一种高效微管靶向天然产物，可诱导有丝分裂阻滞并在亚纳摩尔浓度杀死肿瘤细胞。

CAS号

35846-53-8

分子式

C34H46ClN3O10

主要靶点

Antibiotic|Microtubule Associated

仅限科研使用

Cat No : CM05133

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Synonyms

美坦新|Maitansine|NSC153858|Maitansina|NSC 153858|NSC-153858

验证数据展示

  • CAS No.: 35846-53-8

    Maytansine
    CAS#: 35846-53-8

产品信息

Maytansine, an ansamycin antibiotic originally isolated from the Ethiopian shrub Maytenus serrata, inhibits the assembly of microtubules by binding to tubulin at the rhizoxin binding site.

CAS号 35846-53-8
分子式 C34H46ClN3O10
主要靶点 Antibiotic|Microtubule Associated
主要通路 细胞骨架|微生物学
分子量 692.2
纯度 98.43%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 美坦新|Maitansine|NSC153858|Maitansina|NSC 153858|NSC-153858

溶解度

H2O:Insoluble,DMSO:60 mg/ml (86.68 mM)

参考文献

1.Kusari S, Lamshöft M, Kusari P, Gottfried S, Zühlke S, Louven K, Hentschel U, Kayser O, Spiteller M. Endophytes are hidden producers of maytansine in Putterlickia roots. J Nat Prod. 2014 Dec 26;77(12):2577-84.
2.Tang X, Dai H, Zhu Y, Tian Y, Zhang R, Mei R, Li D. Maytansine-loaded star-shaped folate-core PLA-TPGS nanoparticles enhancing anticancer activity. Am J Transl Res. 2014 Oct 11;6(5):528-37. eCollection 2014.
3.Wings S, Müller H, Berg G, Lamshöft M, Leistner E. A study of the bacterial community in the root system of the maytansine containing plant Putterlickia verrucosa. Phytochemistry. 2013 Jul;91:158-64.
4.Lopus M, Oroudjev E, Wilson L, Wilhelm S, Widdison W, Chari R, Jordan MA. Maytansine and cellular metabolites of antibody-maytansinoid conjugates strongly suppress microtubule dynamics by binding to microtubules. Mol Cancer Ther. 2010 Oct;9(10):2689-99.

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The dilution calculator equation

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