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MN58b

MN58b 是一种选择性的胆碱激酶抑制剂，可抑制磷酸胆碱的合成。它通过诱导凋亡来减少细胞生长，具有抗肿瘤活性。

CAS号

203192-01-2

分子式

C32H40Br2N4

主要靶点

AChR|Apoptosis

仅限科研使用

Cat No : CM03468

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Synonyms

验证数据展示

  • CAS No.: 203192-01-2

    MN58b
    CAS#: 203192-01-2

产品信息

MN58b is a selective inhibitor of choline kinase α (CHKα).

CAS号 203192-01-2
分子式 C32H40Br2N4
主要靶点 AChR|Apoptosis
主要通路 神经科学|凋亡
分子量 640.49
纯度 97.46%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

体内活性

MN58b treatment significantly decreases phosphomonoesters in both HT29 and MDA-MB-231 xenografts. Phosphocholine levels are found to correlate with choline kinase activities[2].

体外活性

MN58b (1-5 μM; 72 hours; SK-PC-1, Suit2 008, IMIM-PC2, and RWP-1 cells) has a marked effect on colony formation at 1 μM, and growth is completely abolished at 5 μM in all the cell lines[1]

溶解度

DMSO:6.41 mg/mL (10 mM)

参考文献

1.Mazarico JM, et al. Choline Kinase Alpha (CHKα) as a Therapeutic Target in Pancreatic Ductal Adenocarcinoma: Expression, Predictive Value, and Sensitivity to Inhibitors. Mol Cancer Ther. 2016 Feb;15(2):323-33.
2.Al-Saffar NM, et al. Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of the choline kinase inhibitor MN58b in human carcinoma models. Cancer Res. 2006 Jan 1;66(1):427-34.

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