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验证数据展示

  • WB analysis using 10338-1-AP (same clone as 10338-1-PBS)

    WB analysis using 10338-1-AP (same clone as 10338-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 10338-1-AP (MLPH antibody) at dilution of 1:15000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 10338-1-PBS in a different storage buffer formulation.

  • IHC staining of human skin cancer using 10338-1-AP (same clone as 10338-1-PBS)

    IHC staining of human skin cancer using 10338-1-AP (same clone as 10338-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human skin cancer tissue slide using 10338-1-AP (Melanophilin antibody at dilution of 1:200 (under 10x lens). This data was developed using the same antibody clone with 10338-1-PBS in a different storage buffer formulation.

  • IHC staining of human skin cancer using 10338-1-AP (same clone as 10338-1-PBS)

    IHC staining of human skin cancer using 10338-1-AP (same clone as 10338-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human skin cancer tissue slide using 10338-1-AP (Melanophilin antibody at dilution of 1:200 (under 40x lens). This data was developed using the same antibody clone with 10338-1-PBS in a different storage buffer formulation.

  • IP experiment of A375 using 10338-1-AP (same clone as 10338-1-PBS)

    IP experiment of A375 using 10338-1-AP (same clone as 10338-1-PBS)

    IP result of anti-Melanophilin (IP:10338-1-AP, 4ug; Detection:10338-1-AP 1:600) with A375 cells lysate 3600ug. This data was developed using the same antibody clone with 10338-1-PBS in a different storage buffer formulation.

  • IF Staining of MCF-7 using 10338-1-AP (same clone as 10338-1-PBS)

    IF Staining of MCF-7 using 10338-1-AP (same clone as 10338-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed MCF-7 cells using Melanophilin antibody (10338-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 10338-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO验证

MLPH Polyclonal antibody, PBS Only

MLPH Polyclonal Antibody for WB, IHC, IF/ICC, IP, Indirect ELISA
Cat No. 10338-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, IF/ICC, IP, Indirect ELISA

别名

Exophilin 3, Exophilin-3, Melanophilin, SLAC2 A, SLAC2A

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

10338-1-PBS targets MLPH in WB, IHC, IF/ICC, IP, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, IF/ICC, IP, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag0316

Product name: Recombinant human MLPH protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 8-236 aa of BC001653

Sequence: SKLTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKIKKESSKRELLSDTAHLNETHCARCLQPYQLLVNSKRQCLECGLFTCKSCGRVHPEEQGWICDPCHLARVVKIGSLEWYYEHVKARFKRFGSAKVIRSLHGRLQGGAGPELISEERSGDSDQTDEDGEPGSEAQAQAQPFGSKKKRLLSVHDFDFEGDSDDSTQPQGHSLHLSSVPEARDSPQSLTDESCSEKA

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 melanophilin
别名 Exophilin 3, Exophilin-3, Melanophilin, SLAC2 A, SLAC2A
计算分子量 66 kDa
观测分子量 66 kDa, 80 kDa
GenBank蛋白编号BC001653
基因名称 MLPH
Gene ID (NCBI) 79083
RRIDAB_2146104
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9BV36
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Melanophilin (Mlph) is a member of the exophilin subfamily of Rab effector proteins. MLPH is a modular protein, forming a ternary complex with the small Ras-related GTPase Rab27A in its GTP-bound form and the motor protein myosin Va. It regulates retention of melanosomes at the peripheral actin cytoskeleton of melanocytes, a process essential for normal mammalian pigmentation. Defects in MLPH are a cause of Griscelli syndrome type 3 (GS3), which is characterized by a silver-gray hair color and abnormal pigment distribution in the hair shaft.

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