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MK-0686

MK-0686 是一种可口服的缓激肽 B1 受体拮抗剂，具有潜在的抗炎活性。

CAS号

1159193-97-1

分子式

C22H19ClF4N2O4

主要靶点

Bradykinin Receptor

仅限科研使用

Cat No : CM08955

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Synonyms

MK0686

验证数据展示

  • CAS No.: 1159193-97-1

    MK-0686
    CAS#: 1159193-97-1

产品信息

MK-0686 is an orally available bradykinin B1 receptor antagonist with potential anti-inflammatory activity.

CAS号 1159193-97-1
分子式 C22H19ClF4N2O4
主要靶点 Bradykinin Receptor
主要通路 G蛋白偶联受体
分子量 486.84
纯度 99.56%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 MK0686

参考文献

1.Tang C, Carr BA, Poignant F, Ma B, Polsky-Fisher SL, Kuo Y, Strong-Basalyga K, Norcross A, Richards K, Eisenhandler R, Carlini EJ, Di Marco CN, Kuduk SD, Yu NX, Raab CE, Rushmore T, Frederick CB, Bock MG, Prueksaritanont T. CYP2C75-involved autoinduction of metabolism in rhesus monkeys of methyl 3-chloro-3'-fluoro-4'-{(1R)-1-[({1-[(trifluoroacetyl)amino]cyclopropyl}carbonyl)a mino]ethyl}-1,1'-biphenyl-2-carboxylate (MK-0686), a bradykinin B1 receptor antagonist. J Pharmacol Exp Ther. 2008 Jun;325(3):935-46.
2.Kuduk SD, et al. Development of orally bioavailable and CNS penetrant biphenylaminocyclopropane carboxamide bradykinin B1 receptor antagonists. J Med Chem. 2007 Jan 25;50(2):272-82.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2