• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

BTYNB

CAS号

304456-62-0

分子式

C12H9BrN2OS

主要靶点

c-Myc|NF-κB|Others

仅限科研使用

Cat No : CM04753

Print datasheet

Synonyms

ES-2|IGROV-1|IMP1|cancer cell|BTYNB|BTYNB IMP1 Inhibitor|cMyc|c-Myc|NF-kB|NF-κB|NFκB|NFkB|MDK 6620|MDK6620|MDK-6620|SK-MEL2

验证数据展示

  • CAS No.: 304456-62-0

    BTYNB
    CAS#: 304456-62-0

产品信息

CAS号 304456-62-0
分子式 C12H9BrN2OS
主要靶点 c-Myc|NF-κB|Others
主要通路 NF-κB 信号通路|细胞周期
分子量 309.18
纯度 99.91%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 ES-2|IGROV-1|IMP1|cancer cell|BTYNB|BTYNB IMP1 Inhibitor|cMyc|c-Myc|NF-kB|NF-κB|NFκB|NFkB|MDK 6620|MDK6620|MDK-6620|SK-MEL2

靶点活性

IMP1 c-Myc mRNA internation:5 μM (IC50)

体外活性

在细胞中，BTYNB通过下调由IMP1调节的几种mRNA转录本来发挥作用。BTYNB破坏c-Myc mRNA稳定性，导致c-Myc mRNA及蛋白质的下调。此外，BTYNB下调β-TrCP1 mRNA并减少核转录因子-κB (NF-κB) 的激活。肿瘤转化翻译调控因子eEF2作为新的IMP1靶向mRNA，从而使BTYNB能够抑制肿瘤细胞蛋白质合成。BTYNB强效抑制含IMP1的卵巢癌和黑色素瘤细胞的增殖，而对IMP1阴性细胞无效。IMP1的过表达可以逆转BTYNB对细胞增殖的抑制作用。BTYNB在集落形成测定中完全阻止了黑色素瘤和卵巢癌细胞的非依附性生长。鉴于其针对c-Myc的作用以及抑制难以靶向的黑色素瘤和卵巢癌细胞的增殖能力，加之其独特的作用机制，BTYNB具有进一步进行治疗评估和机制研究的潜力[1]。

溶解度

DMSO:70 mg/mL (226.41 mM);Ethanol:4 mg/mL (12.94 mM)

参考文献

1.Mahapatra L ,  Andruska N ,  Mao C , et al. A Novel IMP1 Inhibitor, BTYNB, Targets c-Myc and Inhibits Melanoma and Ovarian Cancer Cell Proliferation[J]. Translational Oncology, 2017, 10(5):818-827.
2.Simon M ,  Nadine B ,  Bianca B , et al. The oncofetal RNA-binding protein IGF2BP1 is a druggable, post-transcriptional super-enhancer of E2F-driven gene expression in cancer[J]. Nucleic Acids Research, 2020(15):15.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
×
×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2