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MD2-TLR4-IN-1

MD2-TLR4-IN-1 是一种骨髓分化蛋白 2/toll 样受体 4 (MD2-TLR4) 复合物抑制剂，能够抑制巨噬细胞 LPS 诱导的 TNF-α 和 IL-6 的表达，IC50值分别为 0.89 和 0.53 μM。

CAS号

2249801-12-3

分子式

C22H14Cl2N4O

主要靶点

TLR

仅限科研使用

Cat No : CM06672

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Synonyms

验证数据展示

  • CAS No.: 2249801-12-3

    MD2-TLR4-IN-1
    CAS#: 2249801-12-3

产品信息

MD2-TLR4-IN-1 is a myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex inhibitor.

CAS号 2249801-12-3
分子式 C22H14Cl2N4O
主要靶点 TLR
主要通路 免疫与炎症
分子量 421.28
纯度 99.46%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

溶解度

DMSO:Slightly soluble

参考文献

1.Zhiguo, Liu, Lingfeng, et al. Discovery of 3-(Indol-5-yl)-indazole Derivatives as Novel Myeloid Differentiation Protein 2/Toll-like Receptor 4 Antagonists for Treatment of Acute Lung Injury.[J]. Journal of medicinal chemistry, 2019.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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C1   V1   C2   V2