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McMMAF

McMMAF 是一种保护基团共轭的 MMAF。它是一种具有马来酰亚胺基己酰基接头（MC 接头）的 MMAF 衍生物， MMAF 是一种有效的微管蛋白聚合抑制剂。它可与抗体或其他蛋白质或生物聚合物结合。

CAS号

863971-19-1

分子式

C49H76N6O11

主要靶点

Microtubule Associated

仅限科研使用

Cat No : CM02507

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Synonyms

Maleimidocaproyl monomethylauristatin F

验证数据展示

  • CAS No.: 863971-19-1

    McMMAF
    CAS#: 863971-19-1

产品信息

McMMAF is a protective group-conjugated MMAF. MMAF is a potent tubulin polymerization inhibitor.It is a MMAF derivative having a Maleimidocaproyl linker (MC linker), which is ready to conjugate to antibody or other proteins or biopolymers. Mafodotin is a useful agent for make antibody drug conjugate (ADC) for targeted drug delivery.

CAS号 863971-19-1
分子式 C49H76N6O11
主要靶点 Microtubule Associated
主要通路 细胞骨架
分子量 925.16
纯度 99.65%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 Maleimidocaproyl monomethylauristatin F

体外活性

MMAF induces potent antitumor effects when conjugated via protease cleavable linkers to a monoclonal antibody targeting internalizing, tumor-specific cell surface antigens. MMAF is a new auristatin derivative with a charged C-terminal phenylalanine that attenuates its cytotoxic activity compared to its uncharged counterpart, Monomethyl auristatin E (MMAE). It cannot be used as a drug itself because MMAF is highly toxic. The linker to the monoclonal antibody is stable in extracellular fluid but is cleaved by cathepsin once the conjugate has entered a tumor cell, thus activating the anti-mitotic mechanism.

溶解度

DMSO:100 mg/mL (108.09 mM)

参考文献

1.Polson AG, et al. Antibody-drug conjugates for the treatment of non-Hodgkin's lymphoma: target and linker-drug selection. Cancer Res. 2009 Mar 15;69(6):2358-2364.
2.Jianmin Fang, et al. Anti-her2 antibody and conjugate thereof. US 20160304621 A1.

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