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MBCQ

CAS号

150450-53-6

分子式

C16H12ClN3O2

主要靶点

PDE

仅限科研使用

Cat No : CM10746

Print datasheet

Synonyms

coronary|inhibit|cGMP-PDE|arteries|Phosphodiesterase (PDE)|phosphodiesterase|PGF2α|PDE5|Inhibitor|MBCQ

验证数据展示

  • CAS No.: 150450-53-6

    MBCQ
    CAS#: 150450-53-6

产品信息

CAS号 150450-53-6
分子式 C16H12ClN3O2
主要靶点 PDE
主要通路 代谢
分子量 313.74
纯度 99.45%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 coronary|inhibit|cGMP-PDE|arteries|Phosphodiesterase (PDE)|phosphodiesterase|PGF2α|PDE5|Inhibitor|MBCQ

靶点活性

PDE1:>100 μM (IC50)|PDE2:>100 μM (IC50)|PDE3:>100 μM (IC50)|PDE4:>100 μM (IC50)|PDE5:19 nM (IC50)

体外活性

MBCQ，一个选择性的PDE5抑制剂，显著降低了耐受性和非耐受性组织中由GTN引起的松弛的EC(50)值，但在耐受性静脉中的相对变化最大[1]。

溶解度

DMSO:25 mg/mL (79.68 mM)

参考文献

1.Macpherson J D , Gillespie T D , Dunkerley H A , et al. Inhibition of Phosphodiesterase 5 Selectively Reverses Nitrate Tolerance in the Venous Circulation[J]. Journal of Pharmacology & Experimental Therapeutics, 2006, 317(1):188.
2.Kaneda T , Yamamoto H , Azegami Y , et al. Lack of Cyclic Nucleotide Regulation of MBCQ-induced Relaxation of Rat Ileal Smooth Muscle[J]. J Smooth Muscle Res, 2003, 39(3):47-54.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2