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Levamisole hydrochloride

Levamisole hydrochloride ((-)-Tetramisole hydrochloride) 是驱虫剂和免疫调节剂。它对HSV 病毒有明显抗病毒作用。

CAS号

16595-80-5

分子式

C11H12N2S·HCl

主要靶点

Parasite|HSV|AChR|Phospholipase

仅限科研使用

Cat No : CM00327

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Synonyms

(-)-Tetramisole hydrochloride|盐酸左旋咪唑

验证数据展示

  • CAS No.: 16595-80-5

    Levamisole hydrochloride
    CAS#: 16595-80-5

产品信息

Levamisole hydrochloride is an antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects.

CAS号 16595-80-5
分子式 C11H12N2S·HCl
主要靶点 Parasite|HSV|AChR|Phospholipase
主要通路 微生物学|代谢|神经科学
分子量 240.75
纯度 99.57%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 (-)-Tetramisole hydrochloride|盐酸左旋咪唑

体内活性

Tetramisole leads to the mean faecal egg count rose from 3 weeks after treatment and remain continuously higher than those Closantel or Albendazole treated group up to 12 weeks after treatment. [2] Tetramisole reduces neuronal response amplitude in a dose-dependent manner in mouse cortex. Tetramisole also decreases axonal conduction velocity in mouse cortex. [3] Tetramisole significantly increases the stereotyped behavior (grooming, sniffing, biting and licking and head bobbing) of the mice when compared to the control group. Tetramisole significantly increases stereotyped behavior of the mice on days 3, 5 and 8 in comparison with respective control values. Tetramisole treatments (0.5 and 1 mg/kg) also significantly decreases the time needed to complete the negative geotaxis task and reduces landing foot splay. [4]

体外活性

L-tetramisole (250 and 500 mg/mL) suppresses IFN synthesis in the cells from BALB/c and NZB mice. L-tetramisole (125 mg/mL) inhibits the IFN production only partially and this effect is observed when the IFN production is high. L-tetramisole affects the production of the physiological IFN, but not the production of IFN induced by Newcastle disease virus (NDV) in the peritoneal cells of mice or in L929 cells. [1]

溶解度

DMSO:6.25 mg/mL (25.96 mM)

参考文献

1.Błach-Olszewska Z, et al. Arch Immunol Ther Exp (Warsz), 19
2.Khan FA, et al. Trop Anim Health Prod,1999, 31(4), 193-204.
3.Nowak LG, et al. Subcell Biochem,2015, 76, 239-281.
4.Mohammad FK, et al. Neurotoxicology,2006, 27(2), 153-157.

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