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Lersivirine

CAS号

473921-12-9

分子式

C17H18N4O2

主要靶点

HIV Protease|Reverse Transcriptase

仅限科研使用

Cat No : CM04603

Print datasheet

Synonyms

Inhibitor|Lersivirine|Lersivirine(UK 453061)|NNRTI|NNRTI-resistant|non-nucleoside reverse transcription|Reverse Transcriptase|ReverseTranscriptase|resistant strain|UK453061|UK-453061|UK 453061|3-氰基-5-[[3,5-二乙基-1-(2-羟基乙基)-1H-吡唑-4-基]氧基]苯腈|inhibit|HIV|HIV Protease|HIVProtease|HIV virus|Human immunodeficiency virus

验证数据展示

  • CAS No.: 473921-12-9

    Lersivirine
    CAS#: 473921-12-9

产品信息

CAS号 473921-12-9
分子式 C17H18N4O2
主要靶点 HIV Protease|Reverse Transcriptase
主要通路 蛋白酶体|微生物学|微生物学
分子量 310.35
纯度 98.01%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Inhibitor|Lersivirine|Lersivirine(UK 453061)|NNRTI|NNRTI-resistant|non-nucleoside reverse transcription|Reverse Transcriptase|ReverseTranscriptase|resistant strain|UK453061|UK-453061|UK 453061|3-氰基-5-[[3,5-二乙基-1-(2-羟基乙基)-1H-吡唑-4-基]氧基]苯腈|inhibit|HIV|HIV Protease|HIVProtease|HIV virus|Human immunodeficiency virus

靶点活性

NNRT:119 nM (IC50)

溶解度

DMSO:50 mg/mL (161.11 mM)

参考文献

1.Davis J, et al. The effect of lersivirine, a next-generation NNRTI, on the pharmacokinetics of midazolam and oral contraceptives in healthy subjects. Eur J Clin Pharmacol. 2012 Nov;68(11):1567-72.
2.Mowbray CE, et al. Pyrazole NNRTIs 4: selection of UK-453,061 (lersivirine) as a development candidate. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5857-60.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2