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LYN-1604 dihydrochloride

CAS号

2310109-38-5

分子式

C33H45Cl4N3O2

主要靶点

Apoptosis|Autophagy

仅限科研使用

Cat No : CM14414

Print datasheet

Synonyms

2216753-86-3|2216753-86-3 free base|activator|Apoptosis|anti-tumor|breast|cancer|Autophagy|LYN 1604 Dihydrochloride|LYN 1604 dihydrochloride|LYN1604|LYN 1604|LYN-1604|LYN-1604 2HCl|LYN-1604 2HCl(2216753-86-3 free base)|LYN1604 Dihydrochloride|LYN1604 dihydrochloride|LYN-1604 Dihydrochloride|inhibit|Inhibitor|negative|ULK1|ULK|Unc-51 like kinase|TNBC|triple

验证数据展示

  • CAS No.: 2310109-38-5

    LYN-1604 dihydrochloride
    CAS#: 2310109-38-5

产品信息

CAS号 2310109-38-5
分子式 C33H45Cl4N3O2
主要靶点 Apoptosis|Autophagy
主要通路 凋亡|自噬
分子量 657.54
纯度 99.80%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 2216753-86-3|2216753-86-3 free base|activator|Apoptosis|anti-tumor|breast|cancer|Autophagy|LYN 1604 Dihydrochloride|LYN 1604 dihydrochloride|LYN1604|LYN 1604|LYN-1604|LYN-1604 2HCl|LYN-1604 2HCl(2216753-86-3 free base)|LYN1604 Dihydrochloride|LYN1604 dihydrochloride|LYN-1604 Dihydrochloride|inhibit|Inhibitor|negative|ULK1|ULK|Unc-51 like kinase|TNBC|triple

靶点活性

ULK1:18.94 nM (EC50)

体外活性

LYN-1604被认为是最佳的ULK1激动剂候选物。通过激活ATF3、RAD21和caspase3，LYN-1604诱导了细胞死亡，同时伴随着自噬和凋亡的过程。在体内，LYN-1604通过针对ULK1调控的细胞死亡路径，展现出对TNBC（三阴性乳腺癌）具有潜在的良好治疗效果。

溶解度

DMSO:25 mg/mL (38.02 mM)

参考文献

1.Zhang L , Fu L , Zhang S , et al. Discovery of a small molecule targeting ULK1-modulated cell death of triple negative breast cancer in vitro and in vivo[J]. Chemical Science, 2017, 8(4):2687.

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