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LY2979165

LY2979165 (mGlu2 agonist) 是 mGluR2 的正构激动剂，可用于作为抗抑郁药的研究。

CAS号

1311385-32-6

分子式

C13H22N6O6S

主要靶点

GluR

仅限科研使用

Cat No : CM05090

Print datasheet

Synonyms

mGlu2 agonist

验证数据展示

  • CAS No.: 1311385-32-6

    LY2979165
    CAS#: 1311385-32-6

产品信息

LY2979165 is an orthosteric agonist of mGluR2 and can be used in studies about serving as an anti-depressant.

CAS号 1311385-32-6
分子式 C13H22N6O6S
主要靶点 GluR
主要通路 神经科学
分子量 390.42
纯度 100.00%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 mGlu2 agonist

体内活性

LY2979165 reduces BOLD signal and increases plasma levels of 2812223 in vivo[1].

溶解度

H2O:40 mg/mL (102.5 mM),DMSO:1 mg/mL (2.56 mM),Sonification/heating is recommended.

参考文献

1.Mitul A Mehta, et al. Group II metabotropic glutamate receptor agonist prodrugs LY2979165 and LY2140023 attenuate the functional imaging response to ketamine in healthy subjects. Psychopharmacology (Berl). 2018 Jul;235(7):1875-1886.
2.Hanna L, et al. Differentiating the roles of mGlu2 and mGlu3 receptors using LY541850, an mGlu2 agonist/mGlu3 antagonist. Neuropharmacology. 2013 Mar;66:114-21.
3.Ceolin L, et al. Study of novel selective mGlu2 agonist in the temporo-ammonic input to CA1 neurons reveals reduced mGlu2 receptor expression in a Wistar substrain with an anxiety-like phenotype. J Neurosci. 2011 May 4;31(18):6721-31.
4.Liu W, et al.Pharmacogenetic analysis of the mGlu2/3 agonist LY2140023 monohydrate in the treatment of schizophrenia.Pharmacogenomics J. 2012 Jun;12(3):246-54.
5.Dominguez C, et al. Methyl substitution of 2-aminobicyclo[3.1.0]hexane 2,6-dicarboxylate (LY354740) determines functional activity at metabotropic glutamate receptors: identification of a subtype selective mGlu2 receptor agonist. J Med Chem. 2005 May 19;48(10):3605-12.

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