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Etalocib

Etalocib (LY293111) 是一种具有口服活性的白三烯(LTB4)受体的拮抗剂，抑制 [3H]LTB4结合的 Ki 值为 25 nM。它还可诱导凋亡。它抑制 LTB4诱导的钙动员，lC50值为 20 nM。

CAS号

161172-51-6

分子式

C33H33FO6

主要靶点

LTR|Leukotriene Receptor|Apoptosis

仅限科研使用

Cat No : CM05002

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Synonyms

LY293111|VML295

验证数据展示

  • CAS No.: 161172-51-6

    Etalocib
    CAS#: 161172-51-6

产品信息

Etalocib is a novel diaryl ether carboxylic acid derivative, is a selective and potent inhibitor of the lipoxygenase pathway either via antagonism of the leukotriene B4 (LTB4) receptor or directly through 5'-lipoxygenase. It has antineoplastic activities.

CAS号 161172-51-6
分子式 C33H33FO6
主要靶点 LTR|Leukotriene Receptor|Apoptosis
主要通路 凋亡|G蛋白偶联受体|免疫与炎症
分子量 544.6
纯度 98.92%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 LY293111|VML295

溶解度

DMSO:100 mg/mL (183.62 mM),Sonification is recommended.

参考文献

1.P Marder, et al. Blockade of Human Neutrophil Activation by 2-[2-propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5- Hydroxyphenoxy]propoxy]phenoxy]benzoic Acid (LY293111), a Novel Leukotriene B4 Receptor Antagonist. Biochem Pharmacol. 1995 May 26;49(11):1683-90.
2.Wei-Gang Tong, et al. Leukotriene B4 Receptor Antagonist LY293111 Inhibits Proliferation and Induces Apoptosis in Human Pancreatic Cancer Cells. Clin Cancer Res. 2002 Oct;8(10):3232-42.

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