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LTβR-IN-1

LTβR-IN-1是一种有作用的、具有选择性的淋巴素β受体(LTβR)抑制剂。LTβR-IN-1 对TNF12A 的的 p52 的核易位抑制作用具有选择性，对 TNF-α 受体介导的 p65 的核易位无明显作用，却抑制受 TWEAK 或 Anti-LTβR 刺激的 p52 核易位，IC50为10 μM。LTβR-IN-1通过配体非依赖性方式实现对 NF-kB 信号通路的调节作用。

CAS号

2189366-77-4

分子式

C18H16N4O2

主要靶点

LTR|NF-κB|Others

仅限科研使用

Cat No : CM11303

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Synonyms

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  • CAS No.: 2189366-77-4

    LTβR-IN-1
    CAS#: 2189366-77-4

产品信息

LTβR-IN-1 is a potent and selective lymphin β receptor (LTβR) inhibitor. LTβR-IN-1 has a selective inhibitory effect on the nuclear translocation of p52 of TNF12A, and has no obvious effect on the nuclear translocation of p65 mediated by TNF-α receptor, but inhibits the nuclear translocation of p52 stimulated by TWEAK or Anti-LTβR. Translocation with IC50 of 10 μM. LTβR-IN-1 regulates the NF-kB signaling pathway through a ligand-independent manner.

CAS号 2189366-77-4
分子式 C18H16N4O2
主要靶点 LTR|NF-κB|Others
主要通路 NF-κB信号通路|免疫与炎症|其他
分子量 320.35
纯度 99.09%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

LTβR,p52 translocation:10 μM |LTβR,p52 translocation:0.169 μM

溶解度

DMSO:113 mg/mL (350 mM)

参考文献

1.Henry KL, Kellner D, Bajrami B, et al. CDK12-mediated transcriptional regulation of noncanonical NF-κB components is essential for signaling. Sci Signal. 2018;11(541):eaam8216.

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