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LMPTP INHIBITOR 1 dihydrochloride

CAS号

2310135-46-5

分子式

C28H38Cl2N4O

主要靶点

Phosphatase

仅限科研使用

Cat No : CM05905

Print datasheet

Synonyms

inhibit|Inhibitor|LMPTP inhibitor1|LMPTP inhibitor-1|LMPTP inhibitor 1|LMPTP INHIBITOR 1|LMPTP INHIBITOR 1 dihydrochloride|LMPTP INHIBITOR 1 Dihydrochloride|protein tyrosine phosphatase(PTP)|Phosphatase

验证数据展示

  • CAS No.: 2310135-46-5

    LMPTP INHIBITOR 1 dihydrochloride
    CAS#: 2310135-46-5

产品信息

CAS号 2310135-46-5
分子式 C28H38Cl2N4O
主要靶点 Phosphatase
主要通路 代谢
分子量 517.53
纯度 99.49%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 inhibit|Inhibitor|LMPTP inhibitor1|LMPTP inhibitor-1|LMPTP inhibitor 1|LMPTP INHIBITOR 1|LMPTP INHIBITOR 1 dihydrochloride|LMPTP INHIBITOR 1 Dihydrochloride|protein tyrosine phosphatase(PTP)|Phosphatase

靶点活性

LMPTPA:0.8 μM

体内活性

LMPTP inhibitor 1 dihydrochloride 具有口服生物可利用性，0.03% w/w 的处理后在血清中的平均浓度约为680 nM，而0.05% w/w 的处理后血清浓度可达>3 μM；同时能够逆转肥胖小鼠的糖尿病。LMPTP inhibitor 1 dihydrochloride (0.05% w/w) 抑制LMPTP活性，显著改善了糖尿病DIO小鼠的葡萄糖耐受能力并降低了禁食时的胰岛素水平，而对体重无影响[1]。

体外活性

LMPTP INHIBITOR 1 dihydrochloride 是一种选择性低分子量蛋白酪氨酸磷酸酶抑制剂，对LMPTP-A的IC50为0.8 μM，相比LMPTP-B展现出更强的抑制效果。在人类HepG2肝细胞中，LMPTP INHIBITOR 1 dihydrochloride （10 μM）在胰岛素刺激后还能增强HepG2 IR磷酸化[1]。

溶解度

H2O:50 mg/mL (96.61 mM);DMSO:64 mg/mL (123.66 mM)

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2