• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

LM10

LM10 是有效的色氨酸 2,3-双加氧酶的抑制剂。色氨酸 2,3-双加氧酶是一种无关的肝酶，它可通过犬尿氨酸途径降解色氨酸。它对研究癌症疾病具有潜在的研究价值。

CAS号

1316695-35-8

分子式

C11H8FN5

主要靶点

Others

仅限科研使用

Cat No : CM06608

Print datasheet

Synonyms

验证数据展示

  • CAS No.: 1316695-35-8

    LM10
    CAS#: 1316695-35-8

产品信息

Selective tryptophan 2, 3-dioxygenase (TDO) inhibitor (IC50 values are 0.62 and 2 μM for human and mouse TDO, respectively). Exhibits selectivity for TDO over IDO, MAO-A, MAO-B, and a panel of receptors and transporters. Reduces growth of TDO-expressing P815 mastocytoma tumors in mice. Orally bioavailable.

CAS号 1316695-35-8
分子式 C11H8FN5
主要靶点 Others
主要通路 其他
分子量 229.22
纯度 99.88%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

human TDO:0.62 μM|mouse TDO:2 μM

溶解度

DMSO:22.92 mg/mL(100 mM),Ethanol:4.58 mg/mL(20 mM)

参考文献

1.Pilotte L,etal.Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase.Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2497-502.
2.Huang W,etal.Crystal structure of Drosophila melanogaster tryptophan 2,3-dioxygenase reveals insights into substrate recognition and catalytic mechanism.J Struct Biol. 2013 Mar;181(3):291-9.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
×
×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2