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LDN-212854

CAS号

1432597-26-6

分子式

C25H22N6

主要靶点

TGF-beta/Smad|ALK

仅限科研使用

Cat No : CM06626

Print datasheet

Synonyms

HCC|heterotopic ossification|Huh7|FOP model|EpCAM|BMP|BMPR2 cell|BMP Inhibitor III|BMP9-ID1 signaling|ALK5|ALK4|ALK1|ALK2|ALK3|LDN212854|LDN-212854|LDN 212854|inhibit|Inhibitor|MT cell|Transforming growth factor beta receptors|TGF-b/Smad|TGFb|TGFβ|TGF-β/Smad|TGF-β Receptor|TGFbeta/Smad|TGF-beta|TGFbeta|Smad

验证数据展示

  • CAS No.: 1432597-26-6

    LDN-212854
    CAS#: 1432597-26-6

产品信息

CAS号 1432597-26-6
分子式 C25H22N6
主要靶点 TGF-beta/Smad|ALK
主要通路 血管生成|蛋白酪氨酸激酶|干细胞
分子量 406.48
纯度 99.38%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 HCC|heterotopic ossification|Huh7|FOP model|EpCAM|BMP|BMPR2 cell|BMP Inhibitor III|BMP9-ID1 signaling|ALK5|ALK4|ALK1|ALK2|ALK3|LDN212854|LDN-212854|LDN 212854|inhibit|Inhibitor|MT cell|Transforming growth factor beta receptors|TGF-b/Smad|TGFb|TGFβ|TGF-β/Smad|TGF-β Receptor|TGFbeta/Smad|TGF-beta|TGFbeta|Smad

靶点活性

ALK2:1.3 nM

体内活性

在成肌纤维C2C12细胞中,相比BMP6与BMP4诱导的成骨分化,LDN-212854对BMP6的选择性更高。

体外活性

LDN-212854（6 mg/kg,i.p.）有效地使体内ALK2信号失效,能有效抑制进行性骨化性纤维发育不良的可诱导转基因突变体ALK2小鼠的异位骨化.

溶解度

DMSO:10.42 mg/mL (25.63 mM);2eq.HCl:20.3 mg/mL (50 mM)

参考文献

1.ACS Chem Biol. 2013, 8(6), 1291-1302.
2.Yuan Q, Cao S, Dong Q, et al. ALDH2 Activation Inhibited Cardiac Fibroblast-to-Myofibroblast Transformation Via the TGF-β1/Smad Signaling Pathway[J]. Journal of cardiovascular pharmacology. 2019 Apr;73(4): 248-256.

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