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L-Ascorbic acid

CAS号

50-81-7

分子式

C6H8O6

主要靶点

Apoptosis|Endogenous Metabolite|Reactive Oxygen Species|Calcium Channel

仅限科研使用

Cat No : CM00730

Print datasheet

Synonyms

抗坏血酸|维生素C|Vitamin C|VC|species|ROS|L-抗坏血酸|Inhibitor|inhibit|L Ascorbic acid|L(+)-Ascorbic acid|L-Ascorbic acid|LAscorbic acid|L-Ascorbate|oxygen|ReactiveOxygenSpecies|reactive|Reactive Oxygen Species|collagen|channel|Cav3.2|CalciumChannel|Calcium Channel|cancer|Ca2+ channels|Ca channels|Ascorbic acid|antioxidant|Apoptosis|EndogenousMetabolite|deposition|Electron|Endogenous Metabolite|donor

验证数据展示

  • CAS No.: 50-81-7

    L-Ascorbic acid
    CAS#: 50-81-7

产品信息

CAS号 50-81-7
分子式 C6H8O6
主要靶点 Apoptosis|Endogenous Metabolite|Reactive Oxygen Species|Calcium Channel
主要通路 代谢|离子通道|代谢|代谢|NF-κB 信号通路|免疫与炎症|凋亡
分子量 176.12
纯度 99.89%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 抗坏血酸|维生素C|Vitamin C|VC|species|ROS|L-抗坏血酸|Inhibitor|inhibit|L Ascorbic acid|L(+)-Ascorbic acid|L-Ascorbic acid|LAscorbic acid|L-Ascorbate|oxygen|ReactiveOxygenSpecies|reactive|Reactive Oxygen Species|collagen|channel|Cav3.2|CalciumChannel|Calcium Channel|cancer|Ca2+ channels|Ca channels|Ascorbic acid|antioxidant|Apoptosis|EndogenousMetabolite|deposition|Electron|Endogenous Metabolite|donor

体内活性

方法：为检测辐射保护活性，将 L-Ascorbic acid (1-4.5 g/kg) 腹腔注射给被辐射的 C57BL/6 小鼠。 结果：暴露后立即给予 3 g/kg L-Ascorbic acid 可显著提高小鼠在 7-8 Gy WBI 后的存活率。然而，少于 3 g/kg L-Ascorbic acid 的给药无效，4 g/kg 及以上对小鼠有害。[3] 方法：为研究对健忘症的作用，将 L-Ascorbic acid (60-160 mg/kg) 腹腔注射给 diazepam、scopolamine 和衰老诱导的健忘症 Swiss 小鼠，每天一次，持续 3-8 天。 结果：L-Ascorbic acid 改善了衰老小鼠的学习和记忆，表现为转移潜伏期降低和降压潜伏期增加。[4]

体外活性

方法：人骨肉瘤细胞 MG-63 用 L-Ascorbic acid (62.5-1000 μM) 处理 3-24 h，使用 XTT Assay 检测细胞活力。 结果：当用浓度为 0-250 μM 的 L-Ascorbic acid 处理细胞时，细胞活力始终>95%。当使用更高浓度时，观察到细胞活力的剂量依赖性降低。[1] 方法：黑色素瘤细胞 WM1366 用 L-Ascorbic acid (5-50 μM) 处理 24 h，使用 Western Blot 方法检测靶点蛋白表达水平。 结果：最低浓度的 L-Ascorbic acid (5 μM) 显著降低了人黑色素瘤细胞系中 HIF-1α 蛋白的常氧表达。[2]

溶解度

DMSO:60 mg/mL (340.68 mM);H2O:35.7 mg/mL (202.8 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

参考文献

1.Valenti MT, et al. Ascorbic acid induces either differentiation or apoptosis in MG-63 osteosarcoma lineage. Anticancer Res. 2014 Apr;34(4):1617-27.
2.Miles SL, et al. Ascorbic acid and ascorbate-2-phosphate decrease HIF activity and malignant properties of human melanoma cells. BMC Cancer. 2015 Nov 7;15:867.
3.Sato T, et al. Treatment of irradiated mice with high-dose ascorbic acid reduced lethality. PLoS One. 2015 Feb 4;10(2):e0117020.
4.Parle M, et al. Ascorbic Acid: a promising memory-enhancer in mice. J Pharmacol Sci. 2003 Oct;93(2):129-35.
5.Kida T, et al. Exp Eye Res, 2010, 91(1), 85-91.
6.Wang S, Li F, Qiao R, et al. Arginine-Rich Manganese Silicate Nanobubbles as a Ferroptosis-Inducing Agent for Tumor-Targeted Theranostics[J]. ACS nano. 2018 Dec 26;12(12):12380-12392.

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