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Kynurenic Acid

Kynurenic Acid is a broad spectrum glutamatergic antagonist which can antagonize NMDA, kainate and AMPA receptors.

CAS号

492-27-3

分子式

C10H7NO3

主要靶点

AMPAR

仅限科研使用

Cat No : CM00217

Print datasheet

Synonyms

NSC 58973

验证数据展示

  • CAS No.: 492-27-3

    Kynurenic Acid
    CAS#: 492-27-3

  • Kynurenic Acid<br/>CAS#: 492-27-3

    Kynurenic Acid
    CAS#: 492-27-3

产品信息

Kynurenic acid (KYNA) is an endogenous antagonist of glutamate in the central nervous system. It is most active as an antagonist at receptors sensitive to N‐methyl‐D‐aspartate (NMDA) which regulate neuronal excitability and plasticity, brain development and behaviour. Peripheral administration of kynurenic acid, at a dose that caused plasma levels to increase 430-fold, resulted in only 4-fold increases in striatal ECF(extracellular fluid) concentrations. KYNA has a significant protective effect on liver injury induced by thioacetamide (TAA).

CAS号 492-27-3
分子式 C10H7NO3
主要靶点 AMPAR
主要通路 Neuronal Signaling
分子量 189.1675
MDL NO MFCD00149476
Pubchem ID 3845
纯度 97%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件
粉末 -20°C 3年
液体 -80°C 1年
运输条件 Shipped in cold pack
别名 NSC 58973

溶解度

DMSO10 mg/mL
WaterInsoluble
EthanolInsoluble

参考文献

1Sekine A, Okamoto M, et al. Amino acids inhibit kynurenic acid formation via suppression of kynurenine uptake or kynurenic acid synthesis in rat brain in vitro. Springerplus. 2015 Feb 1;4:48.
2Di Serio C, Cozzi A, et al. Kynurenic acid inhibits the release of the neurotrophic fibroblast growth factor (FGF)-1 and enhances proliferation of glia cells, in vitro. Cell Mol Neurobiol. 2005 Sep;25(6):981-93.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2