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验证数据展示

  • WB analysis of A549 using 19965-1-AP (same clone as 19965-1-PBS)

    WB analysis of A549 using 19965-1-AP (same clone as 19965-1-PBS)

    A549 cells were subjected to SDS PAGE followed by western blot with 19965-1-AP (Kir2.1 antibody) at dilution of 1:200 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 19965-1-PBS in a different storage buffer formulation.

  • IHC staining of human brain using 19965-1-AP (same clone as 19965-1-PBS)

    IHC staining of human brain using 19965-1-AP (same clone as 19965-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human brain tissue slide using 19965-1-AP (Kir2.1 antibody at dilution of 1:50. This data was developed using the same antibody clone with 19965-1-PBS in a different storage buffer formulation.

Kir2.1 Polyclonal antibody, PBS Only

Kir2.1 Polyclonal Antibody for WB, Indirect ELISA
Cat No. 19965-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, Indirect ELISA

别名

KCNJ2, IRK-1, IRK1, IRK 1, hIRK1

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

19965-1-PBS targets Kir2.1 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原 Peptide 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 potassium inwardly-rectifying channel, subfamily J, member 2
别名 KCNJ2, IRK-1, IRK1, IRK 1, hIRK1
计算分子量 48 kDa
观测分子量 50 kDa, 60 kDa
GenBank蛋白编号NM_000891
基因名称 Kir2.1
Gene ID (NCBI) 3759
RRIDAB_10859827
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDP63252
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

KCNJ2, also named as HHBIRK1, HHIRK1, IRK1, KIR2.1, LQT7 and SQT3, belongs to the inward rectifier-type potassium channel family. KCNJ2 probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ2 can be blocked by extracellular barium or cesium. Defects in KCNJ2 are the cause of long QT syndrome type 7 (LQT7). Defects in KCNJ2 are the cause of short QT syndrome type 3 (SQT3). The antibody recognizes the C-term of KCNJ2.