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KML29

CAS号

1380424-42-9

分子式

C24H21F6NO7

主要靶点

Lipase

仅限科研使用

Cat No : CM04966

Print datasheet

Synonyms

2-AG|allodynia|inhibit|HFIP|Inhibitor|KML 29|KML29|KML-29|MAGL|LPS|Monoacylglycerol lipase

验证数据展示

  • CAS No.: 1380424-42-9

    KML29
    CAS#: 1380424-42-9

产品信息

CAS号 1380424-42-9
分子式 C24H21F6NO7
主要靶点 Lipase
主要通路 代谢
分子量 549.42
纯度 98.65%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 2-AG|allodynia|inhibit|HFIP|Inhibitor|KML 29|KML29|KML-29|MAGL|LPS|Monoacylglycerol lipase

靶点活性

MAGL (human):5.9 nM|MAGL (rat):43 nM|2-AG:2.5 nM|MAGL (mouse):15 nM|AEA:>50 μM

体内活性

DprE1-IN-2 has efficacy in a rodent model of tuberculosis.

溶解度

DMSO:50 mg/mL (91 mM)

参考文献

1.Chang JW, et al. Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. Chem Biol. 2012 May 25;19(5):579-588.
2.Ignatowska-Jankowska BM,et al. In vivo characterization of the highly selective monoacylglycerol lipase inhibitor KML29: antinociceptive activity without cannabimimetic side effects. Br J Pharmacol. 2014 Mar;171(6):1392-1407.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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