• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

Jatrorrhizine chloride

CAS号

6681-15-8

分子式

C20H20ClNO4

主要靶点

5-HT Receptor|OCT|Antibacterial|AChE|Others

仅限科研使用

Cat No : CM05019

Print datasheet

Synonyms

depressive disorder|Cytotoxic|E. histolytica|inhibit|falciparum|Cholinesterase (ChE)|Bacterial|antidepressant|antidepressant-like|antiamoebic|Alzheimer's disease|antimicrobial|antioxidant|antiplasmodial|alkaloid|AChE|5HT Receptor|5-HT Receptor|5-hydroxytryptamine Receptor|5HTReceptor|Inhibitor|Jatrorrhizine chloride|Jatrorrhizine Chloride|Jatrorrhizine|PMAT|quaternary isoquinoline|OCT|Neprotine Chloride|Neprotine chloride|neuroprotective|Serotonin Receptor|Yatrorhizine Chloride|Yatrorhizine chloride|盐酸药根碱

验证数据展示

  • CAS No.: 6681-15-8

    Jatrorrhizine chloride
    CAS#: 6681-15-8

产品信息

CAS号 6681-15-8
分子式 C20H20ClNO4
主要靶点 5-HT Receptor|OCT|Antibacterial|AChE|Others
主要通路 神经科学|离子通道|微生物学|G 蛋白偶联受体|神经科学
分子量 373.8
纯度 99.79%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 depressive disorder|Cytotoxic|E. histolytica|inhibit|falciparum|Cholinesterase (ChE)|Bacterial|antidepressant|antidepressant-like|antiamoebic|Alzheimer's disease|antimicrobial|antioxidant|antiplasmodial|alkaloid|AChE|5HT Receptor|5-HT Receptor|5-hydroxytryptamine Receptor|5HTReceptor|Inhibitor|Jatrorrhizine chloride|Jatrorrhizine Chloride|Jatrorrhizine|PMAT|quaternary isoquinoline|OCT|Neprotine Chloride|Neprotine chloride|neuroprotective|Serotonin Receptor|Yatrorhizine Chloride|Yatrorhizine chloride|盐酸药根碱

靶点活性

AChE:872 nM (IC50)

体外活性

有机阳离子转运体(OCTs)和质膜单胺转运体(PMAT)是主要的uptake-2转运体。Jatrorrhizine chloride显著以浓度依赖的方式抑制PMAT介导的MPP+摄取（IC50：1.05 μM）。相较于PMAT介导的抑制作用，Jatrorrhizine chloride对由hOCT2和hOCT3介导的5-HT和去甲肾上腺素(NE)摄取显示出更强的抑制效力。

溶解度

DMSO:8 mg/mL (21.4 mM)

参考文献

1.Sun S, et al. Jatrorrhizine reduces 5-HT and NE uptake via inhibition of uptake-2 transporters and produces antidepressant-like action in mice. Xenobiotica. 2019 Oct;49(10):1237-1243.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
×
×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2