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Jatrorrhizine chloride

Jatrorrhizine chloride (Neprotine chloride) 是从黄连中分离得到的生物碱，具有神经保护、抗菌、抗氧化和抗疟原虫活性。它通过抑制摄取2转运蛋白的活性减少血清素和去甲肾上腺素的摄取。它是具有口服活性的乙酰胆碱酯酶抑制剂。

CAS号

6681-15-8

分子式

C20H20ClNO4

主要靶点

5-HT Receptor|OCT|Antibacterial|AChE|Others

仅限科研使用

Cat No : CM05019

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Synonyms

Yatrorhizine chloride|盐酸药根碱|Neprotine chloride

验证数据展示

  • CAS No.: 6681-15-8

    Jatrorrhizine chloride
    CAS#: 6681-15-8

产品信息

Jatrorrhizine chloride (Neprotine chloride) is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 hippocampal neurons.

CAS号 6681-15-8
分子式 C20H20ClNO4
主要靶点 5-HT Receptor|OCT|Antibacterial|AChE|Others
主要通路 G蛋白偶联受体|离子通道|神经科学|微生物学|其他
分子量 373.8
纯度 99.79%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 Yatrorhizine chloride|盐酸药根碱|Neprotine chloride

靶点活性

AChE:872 nM (IC50)

体外活性

Organic cation transporters (OCTs) and the plasma membrane monoamine transporter (PMAT) are major uptake-2 transporters. Jatrorrhizine chloride significantly inhibits the PMAT-mediated MPP+ uptake in a concentration-dependent manner (IC50: 1.05 μM). Jatrorrhizine chloride demonstrates a more powerful inhibition on 5-HT and norepinephrine (NE) uptake mediated by hOCT2 and hOCT3 than that mediated by PMAT.

溶解度

DMSO:5 mg/mL (13.38 mM)

参考文献

1.Sun S, et al. Jatrorrhizine reduces 5-HT and NE uptake via inhibition of uptake-2 transporters and produces antidepressant-like action in mice. Xenobiotica. 2019 Oct;49(10):1237-1243.

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