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JX06

JX06 是一种选择性共价PDK 抑制剂，抑制PDK1,PDK2和PDK3，IC50值分别为 49 nM，101 nM 和 313 nM。它以不可逆的方式与半胱氨酸残基共价结合来抑制PDK1活性，具有抗肿瘤活性。

CAS号

729-46-4

分子式

C10H16N2O2S4

主要靶点

Apoptosis|PDK|Dehydrogenase

仅限科研使用

Cat No : CM05827

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Synonyms

验证数据展示

  • CAS No.: 729-46-4

    JX06
    CAS#: 729-46-4

产品信息

JX06, a potent, selective and covalent PDK inhibitor, inhibits PDK1, PDK2 and PDK3 with IC50 of 49 nM, 101 nM and 313 nM respectively.

CAS号 729-46-4
分子式 C10H16N2O2S4
主要靶点 Apoptosis|PDK|Dehydrogenase
主要通路 代谢|凋亡|PI3K/Akt/mTOR信号通路
分子量 324.5
纯度 99.66%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

PDK2:101 nM (IC50)|PDK1:49 nM (IC50)|PDK3:313 nM (IC50)

溶解度

DMSO:27.5 mg/mL (84.74 mM)

参考文献

1.Sun W , Xie Z , Liu Y , et al. JX06 Selectively Inhibits Pyruvate Dehydrogenase Kinase PDK1 by a Covalent Cysteine Modification[J]. Cancer Research, 2015:4923-4936.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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C1   V1   C2   V2