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JSH-23

JSH-23 是NF-κB 抑制剂，作用于脂多糖刺激的巨噬细胞 RAW 264.7，抑制 NF-κB 转录活性(IC50=7.1 μM)，抑制 NF-κB p65 的核易位而不影响 IκBα 降解。

CAS号

749886-87-1

分子式

C16H20N2

主要靶点

NF-κB

仅限科研使用

Cat No : CM05273

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Synonyms

验证数据展示

  • CAS No.: 749886-87-1

    JSH-23
    CAS#: 749886-87-1

产品信息

JSH-23, an NF-κB inhibitor（IC50= 7.1 μM）, suppresses the transcriptional activity.

CAS号 749886-87-1
分子式 C16H20N2
主要靶点 NF-κB
主要通路 NF-κB信号通路
分子量 240.34
纯度 99.67%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

NF-κB:7.1 μM

体内活性

在RAW 264.7细胞中,JSH-23<100 μM时没有表现出明显的毒性作用,同时能够抑制脂多糖诱导的凋亡染色质浓缩。在老鼠小脑原代细胞中,JSH-23抑制脂多糖诱导的NF-κB p65核转运,而不影响IκBα降解。

体外活性

在糖尿病大鼠体内,JSH-23（3 mg/kg）能够减少神经炎症,并提高抗氧化防御明显逆转神经传导,最终改善神经血流量不足.

溶解度

DMSO:45 mg/mL (187.2 mM),H2O:<1 mg/mL,Ethanol:16 mg/mL (66.6 mM)

细胞实验

Macrophages RAW 264.7 are incubated with various concentrations of JSH-23 compound for 24 h. The cells are treated with WST-1 solution and absorbance is measured at 450 nm.(Only for Reference)

参考文献

1.Shin HM, et al. FEBS Lett. 2004, 571(1-3), 50-54.
2.Arias-Salvatierra D, et al. Cell Signal. 2011, 23(2), 425-435.
3.Kasparkova J, et al. FEBS J. 2014, doi: 10.1111/febs.12711.
4.Kumar A, et al. Diabetes Obes Metab. 2011, 13(8), 750-758.
5.Song H, Tang X, Li X, et al. HLJ2 Effectively Ameliorates Colitis-Associated Cancer via Inhibition of NF-κB and Epithelial–Mesenchymal Transition[J]. Drug Design, Development and Therapy. 2020, 14: 4291.
6.Lai X, Wang M, Zhu Y, et al. ZnO NPs delay the recovery of psoriasis-like skin lesions through promoting inflammation and keratinocyte apoptosis via nuclear translocation of phosphorylated NF-κB p65 and cysteine deficiency[J]. Journal of Hazardous Materials. 2020: 124566.

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