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JQEZ5

CAS号

1913252-04-6

分子式

C30H38N8O2

主要靶点

Histone Methyltransferase

仅限科研使用

Cat No : CM04571

Print datasheet

Synonyms

inhibit|H3K27me3|Histone Methyltransferase|HistoneMethyltransferase|EZH2|antitumor|PRC2|methionine|Inhibitor|JQEZ 5|JQEZ5|JQEZ-5|S-adenosyl

验证数据展示

  • CAS No.: 1913252-04-6

    JQEZ5
    CAS#: 1913252-04-6

产品信息

CAS号 1913252-04-6
分子式 C30H38N8O2
主要靶点 Histone Methyltransferase
主要通路 表观遗传
分子量 542.68
纯度 98.14%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 inhibit|H3K27me3|Histone Methyltransferase|HistoneMethyltransferase|EZH2|antitumor|PRC2|methionine|Inhibitor|JQEZ 5|JQEZ5|JQEZ-5|S-adenosyl

体外活性

JQEZ5 在 0.5 至 5 μM 的浓度范围内，能够抑制初级人类 CD34+ 慢性髓性白血病 (CML) 干细胞/祖细胞的集落形成，但不影响非癌性人类 CD34+ 血液干细胞/祖细胞。

溶解度

DMSO:25 mg/mL (46.07 mM)

参考文献

1.Xie H , Peng C , Huang J , et al. Chronic Myelogenous Leukemia- Initiating Cells Require Polycomb Group Protein EZH2[J]. Cancer Discovery, 2016, 6(11).

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
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×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2