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JQEZ5

JQEZ5 是一种选择性EZH2赖氨酸甲基转移酶抑制剂，具有抗肿瘤作用。它以 SAM 竞争性方式抑制PRC2的酶功能，IC50为 80 nM。

CAS号

1913252-04-6

分子式

C30H38N8O2

主要靶点

Histone Methyltransferase

仅限科研使用

Cat No : CM04571

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Synonyms

验证数据展示

  • CAS No.: 1913252-04-6

    JQEZ5
    CAS#: 1913252-04-6

产品信息

JQEZ5 is an inhibitor of EZH2 lysine methyltransferase (IC50 = 11.1 nM).

CAS号 1913252-04-6
分子式 C30H38N8O2
主要靶点 Histone Methyltransferase
主要通路 表观遗传
分子量 542.68
纯度 98.14%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

体外活性

JQEZ5 inhibits colony formation of primary human CD34+ chronic myelogenous leukemia (CML) stem/progenitor cells but not non-cancerous human CD34+ hematopoietic stem/progenitor cells when used at concentrations ranging from 0.5 to 5 μM

溶解度

DMSO:25 mg/mL (46.07 mM)

参考文献

1.Xie H , Peng C , Huang J , et al. Chronic Myelogenous Leukemia- Initiating Cells Require Polycomb Group Protein EZH2[J]. Cancer Discovery, 2016, 6(11).

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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C1   V1   C2   V2