JAB1 Polyclonal antibody
JAB1 Polyclonal Antibody for ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human, mouse, rat
Applications
ELISA
Conjugate
Unconjugated
验证数据展示
Planning an IHC experiment? We recommend our IHCeasy COPS5/JAB1 Ready-To-Use IHC Kit. COPS5/JAB1 primary antibody included.
产品信息
10080-1-AP targets JAB1 in ELISA applications and shows reactivity with human, mouse, rat samples.
Tested Applications | ELISA |
Tested Reactivity | human, mouse, rat |
Immunogen | JAB1 fusion protein Ag0126 种属同源性预测 |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Full Name | COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) |
Synonyms | COPS5, CSN5, JAB1, MOV 34, SGN5, Signalosome subunit 5 |
Calculated Molecular Weight | 37 kDa |
GenBank Accession Number | BC001187 |
Gene Symbol | COPS5 |
Gene ID (NCBI) | 10987 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
UNIPROT ID | Q92905 |
Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2.