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Isoquercetin

Isoquercetin (3-Glucosylquercetin) 是天然存在的多酚，具有抗氧化，抗增殖和抗炎特性。它通过调节核因子-κB 转录调节系统调节一氧化氮合酶 2 的表达。它通过 Nrf2/ARE 抗氧化剂信号传导途径减轻乙醇诱导的肝毒性，氧化应激和炎症反应。它具有高生物利用度和低毒性，是预防糖尿病妊娠出生缺陷的有希望的候选药物。

CAS号

482-35-9

分子式

C21H20O12

主要靶点

NO Synthase|Wnt/beta-catenin|NF-κB

仅限科研使用

Cat No : CM00297

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Synonyms

3-Glucosylquercetin|Hirsutrin|Quercetin 3-o-glucopyranoside|异槲皮苷|Isoquercitrin|槲皮素-3-葡萄糖苷

验证数据展示

  • CAS No.: 482-35-9

    Isoquercetin
    CAS#: 482-35-9

产品信息

1. Isoquercitrin is a potential stimulator of bone mineralization used for prophylaxis of osteoporotic disorders. 2. Isoquercitrin may be as a potential therapeutic agent against neurodegeneration in Parkinson's disease. 3. Isoquercitrin is an inhibitor of Wnt/β-catenin and may be as a potential novel anti-tumoral agent, such as against human pancreati、 liver cancer related to opioid receptors and to the activation of the mitogen-activated protein kinase (MAPK) signalling pathway. .

CAS号 482-35-9
分子式 C21H20O12
主要靶点 NO Synthase|Wnt/beta-catenin|NF-κB
主要通路 NF-κB信号通路|干细胞|免疫与炎症|细胞骨架
分子量 464.37
纯度 99.29%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 3-Glucosylquercetin|Hirsutrin|Quercetin 3-o-glucopyranoside|异槲皮苷|Isoquercitrin|槲皮素-3-葡萄糖苷

溶解度

DMSO:83 mg/mL (178.74 mM)

参考文献

1.Isoquercitrin and polyphosphate co-enhance mineralization of human osteoblast-like SaOS-2 cells via separate activation of two RUNX2 cofactors AFT6 and Ets1[J]. Biochemical Pharmacology, 2014, 89(3):413-421.

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