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Isoastilbin

CAS号

54081-48-0

分子式

C21H22O11

主要靶点

Antibacterial|Anti-infection|Tyrosinase

仅限科研使用

Cat No : CM06731

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Synonyms

Tyrosinase|异落新妇苷|neuroprotective|Isoastilbin|Inhibitor|inhibit|Bacterial|anti-apoptotic|Antifection|Alzheimer's|antimicrobial|Anti-infection|Antiinfection|Antioxidation|glycoside|dihydroflavonol|disease

验证数据展示

  • CAS No.: 54081-48-0

    Isoastilbin
    CAS#: 54081-48-0

产品信息

CAS号 54081-48-0
分子式 C21H22O11
主要靶点 Antibacterial|Anti-infection|Tyrosinase
主要通路 微生物学|微生物学|蛋白酶体
分子量 450.39
纯度 99.95%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Tyrosinase|异落新妇苷|neuroprotective|Isoastilbin|Inhibitor|inhibit|Bacterial|anti-apoptotic|Antifection|Alzheimer's|antimicrobial|Anti-infection|Antiinfection|Antioxidation|glycoside|dihydroflavonol|disease

靶点活性

GTase:54.3 μg/mL (IC50)

体外活性

粗提取物经抗微生物活性检测，针对Streptococcus sobrinus及葡萄糖基转移酶(GTase)抑制作用进行评估。其中十四份提取物在100 μg/ml的浓度下对S. sobrinus的生长抑制率超过50%，六份提取物对GTase的活性抑制率也超过50%。Koompassia malaccensis（kempas）提取物在相同浓度下对S. sobrinus生长的抑制率达90%，对GTase活性的抑制率达80%。通过使用Sephadex LH-20柱色谱和制备用高效液相色谱法，对kempas粗提取物进行了分离，从而分离出四种化合物A、B、C和D。通过1H和13C核磁共振（NMR）光谱及其他二维NMR技术（COSY、HMBC和HMQC），确定这些化合物分别为taxifolin及flavanonol rhamnoside异构体neoastilbin、astilbin和Isoastilbin。这些化合物在9.3242.7 μg/ml的浓度范围内均显著抑制了S. sobrinus的生长，并显示出27.4-57.3 μg/ml范围内的GTase抑制活性的IC50值[1]。

溶解度

DMSO:25 mg/mL (55.51 mM)

参考文献

1.Antimicrobial activity against Streptococcus sobrinus and glucosyltransferase inhibitory activity of taxifolin and some flavanonol rhamnosides from kempas (Koompassia malaccensis) extractsJ. Wood Sci., 2009, 55(4):308-13.

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