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Ingenol

Ingenol ((-)-Ingenol) 是一种PKC 激活剂，Ki 值为 30 μM，具有抗肿瘤活性。 从 Ingenol 酯中配制新的衍生物可能是开发新的先导化合物以重新激活潜伏 HIV 的创新方法。Ingenol mebutate 是治疗光化性角化病的有效方法。

CAS号

30220-46-3

分子式

C20H28O5

主要靶点

PKC

仅限科研使用

Cat No : CM06018

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Synonyms

巨大戟醇|(-)-Ingenol|巨大戟二萜醇

验证数据展示

  • CAS No.: 30220-46-3

    Ingenol
    CAS#: 30220-46-3

产品信息

1. Ingenol mebutate is an effective treatment for actinic keratosis. 2. Formulating novel derivatives from Ingenol esters may be an innovative approach to develop new lead compounds to reactivate latent HIV. 3. Ingenol is a weak PKC activator and possesses important anticancer activity.

CAS号 30220-46-3
分子式 C20H28O5
主要靶点 PKC
主要通路 表观遗传|细胞骨架
分子量 348.43
纯度 99.87%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 巨大戟醇|(-)-Ingenol|巨大戟二萜醇

靶点活性

PKC:30 μM(Ki)

溶解度

DMSO:50 mg/mL (143.5 mM)

参考文献

1.Batalla A , Flórez, á, Feal C , et al. Clinical Response to Ingenol Mebutate in Patients With Actinic Keratoses[J]. Actas Dermo-Sifiliográficas (English Edition), 2015, 106(10):e55-e61.

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