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Indirubin-3′-oxime

CAS号

667463-82-3

分子式

C16H11N3O2

主要靶点

GSK-3|JNK|CDK

仅限科研使用

Cat No : CM11349

Print datasheet

Synonyms

CDK|cdk|chondrocytes|collagen|antiplatelet|I3O|indirubin|Indirubin 3′ oxime|Indirubin-3'-monoxime|Indirubin3′oxime|Indirubin-3′-oxime|induced|IDR3O|Glycogen synthase kinase-3|Glycogen synthase kinase 3|GSK-3|GSK3|Cyclin dependent kinase|JNK|Inhibitor|inhibit|MEF2D|phosphorylation

验证数据展示

  • CAS No.: 667463-82-3

    Indirubin-3′-oxime
    CAS#: 667463-82-3

产品信息

CAS号 667463-82-3
分子式 C16H11N3O2
主要靶点 GSK-3|JNK|CDK
主要通路 细胞周期|MAPK 信号通路|PI3K/Akt/mTOR 信号通路|干细胞
分子量 277.28
纯度 98.34%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 CDK|cdk|chondrocytes|collagen|antiplatelet|I3O|indirubin|Indirubin 3′ oxime|Indirubin-3'-monoxime|Indirubin3′oxime|Indirubin-3′-oxime|induced|IDR3O|Glycogen synthase kinase-3|Glycogen synthase kinase 3|GSK-3|GSK3|Cyclin dependent kinase|JNK|Inhibitor|inhibit|MEF2D|phosphorylation

靶点活性

JNK3:1 μM (IC50)|JNK1:0.8 μM (IC50)|JNK2:1.4 μM (IC50)

体内活性

indirubin-3'-monoxime 提高了暴露于β淀粉样肽25-35（Aβ25-35）的SH-SY5Y细胞的形态和存活率，通过减少Ser199和Thr205处的tau蛋白磷酸化，抑制了细胞凋亡。此外，indirubin-3'-monoxime抑制了糖原合成酶激酶-3β（GSK-3β）的磷酸化。indirubin-3'-monoxime通过GSK-3β介导的机制，抑制了tau蛋白过度磷酸化，减少了Aβ25-35诱导的细胞凋亡。这表明indirubin-3'-monoxime是阿尔茨海默病的候选化合物。

体外活性

I3M + Tq组合在LC模型中通过抑制Akt/mTOR/NFκB信号传导途径显现出明确的效果。

溶解度

DMSO:55 mg/mL (198.36 mM)

参考文献

1.Dera A A ,  Rajagopalan P ,  Fayi M A , et al. Indirubin-3-monoxime and thymoquinone exhibit synergistic efficacy as therapeutic combination in in-vitro and in-vivo models of Lung cancer[J]. Archives of Pharmacal Research, 2020, 43(10).

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