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Imeglimin hydrochloride

Imeglimin hydrochloride (EMD 387008 hydrochloride) 是一种口服降糖剂。Imeglimin 可改善胰岛素敏感性，能够抑制活性氧的产生、增加线粒体 DNA、改善线粒体功能。

CAS号

775351-61-6

分子式

C6H14ClN5

主要靶点

Mitochondrial Metabolism|Reactive Oxygen Species

仅限科研使用

Cat No : CM06354

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Synonyms

EMD 387008 hydrochloride|(6R)-1,6-二氢-N2,N2,6-三甲基-1,3,5-三嗪-2,4-二胺盐酸盐

验证数据展示

  • CAS No.: 775351-61-6

    Imeglimin hydrochloride
    CAS#: 775351-61-6

产品信息

Imeglimin hydrochloride prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration.

CAS号 775351-61-6
分子式 C6H14ClN5
主要靶点 Mitochondrial Metabolism|Reactive Oxygen Species
主要通路 代谢|免疫与炎症|NF-κB信号通路
分子量 191.66
纯度 100.00%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 EMD 387008 hydrochloride|(6R)-1,6-二氢-N2,N2,6-三甲基-1,3,5-三嗪-2,4-二胺盐酸盐

体外活性

Imeglimin dramatically decreased reactive oxygen species production, inhibiting specifically reverse electron transfer through complex I. Imeglimin prevents hyperglycemia-induced cell death in HMEC-1 through inhibition of PTP opening without inhibiting mitochondrial respiration nor affecting cellular energy status[1].

溶解度

DMSO:25 mg/mL (130.44 mM)

参考文献

1.Detaille D , Vial G , Borel A L , et al. Imeglimin prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration[J]. Cell death discovery, 2016, 2:15072.
2.Vuylsteke V , Chastain L M , Maggu G A , et al. Imeglimin: A Potential New Multi-Target Drug for Type 2 Diabetes[J]. Drugs in R&D, 2015, 15(3):227-232.

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