IU1-248

CAS号

2307472-03-1

分子式

C20H23N3O2

主要靶点

DUB

仅限科研使用

Cat No : CM11109

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Synonyms

USP14|Inhibitor|inhibit|IU1 248|IU1248|IU-1-248|IU1-248|DUBs|Deubiquitinase



产品信息

CAS号 2307472-03-1
分子式 C20H23N3O2
主要靶点 DUB
主要通路 泛素化|DNA 损伤和修复|细胞周期
分子量 337.42
纯度 99.30%, 此纯度可做参考,具体纯度与批次有关系,可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 USP14|Inhibitor|inhibit|IU1 248|IU1248|IU-1-248|IU1-248|DUBs|Deubiquitinase

靶点活性

USP14:0.83?μM

体外活性

IU1-248对USP14展现出0.83μM的IC50值,相较IU1(IC50=12.25μM)[1],其效能提高了10倍。

溶解度

DMSO:80 mg/mL (237.09 mM)

参考文献

1.Yiwei Wang, et al. Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade. Cell Res. 2018 Dec;28(12):1186-1194.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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