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Givinostat hydrochloride monohydrate

Givinostat hydrochloride monohydrate (ITF2357) 是一种HDAC 抑制剂，对HDAC1和HDAC3的IC50分别为 198 nM 和 157 nM。

CAS号

732302-99-7

分子式

C24H27N3O4·HCl·H2O

主要靶点

HDAC

仅限科研使用

Cat No : CM04410

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Synonyms

ITF-2357 hydrochloride monohydrate|Givinostat|吉维司他|Gavinostat hydrochloride monohydrate|ITF2357

验证数据展示

  • CAS No.: 732302-99-7

    Givinostat hydrochloride monohydrate
    CAS#: 732302-99-7

产品信息

Givinostat hydrochloride monohydrate is an HDAC inhibitor.

CAS号 732302-99-7
分子式 C24H27N3O4·HCl·H2O
主要靶点 HDAC
主要通路 DNA损伤和修复|表观遗传
分子量 475.97
纯度 98.09%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 ITF-2357 hydrochloride monohydrate|Givinostat|吉维司他|Gavinostat hydrochloride monohydrate|ITF2357

靶点活性

HD1-B:7.5 nM|HD1-A:16 nM|HD2:10 nM

溶解度

Ethanol:1 mg/mL(2.1 mM),DMSO:88 mg/mL (184.9 mM),H2O:<1 mg/mL

参考文献

1.Leoni F, et al. Mol Med, 2005, 11(1-12), 1-15.
2.Golay J, et al. Leukemia, 2007,21(9), 1892-1900.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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C1   V1   C2   V2