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IKK 16 HCl

IKK 16 HCl is a selective inhibitor of IκB kinase (IKK) with IC50s of 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively.

CAS号

1186195-62-9

分子式

C28H30ClN5OS

主要靶点

IKK

仅限科研使用

Cat No : CM04723

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Synonyms

验证数据展示

  • CAS No.: 1186195-62-9

    IKK 16 HCl
    CAS#: 1186195-62-9

  • IKK 16 HCl<br/>CAS#: 1186195-62-9

    IKK 16 HCl
    CAS#: 1186195-62-9

产品信息

IκB kinase (IKK) has emerged as a promising target for the development of novel anti-inflammatory and anti-rheumatic drugs. IKK 16 is an IKK inhibitor with IC50 values of 40, 200, and 70nM for IKK2, IKK1, and IKK complex[1]. It also inhibits leucine-rich repeat kinase-2 with an IC50 value of 50nM[2]. The administration of IKK 16 (30mg/kg, s.c.; or 30mg/kg, p.o.) one hour prior to LPS challenge resulted in significant inhibition of TNFα into the plasma of rats (86% and 75%, respectively). IKK 16 at a dose of 10mg/kg (s.c.) also led to 50% inhibition of neutrophil extravasation in a mouse model of thioglycollate-induced peritonitis[1].

CAS号 1186195-62-9
分子式 C28H30ClN5OS
主要靶点 IKK
主要通路 NF-κB
分子量 520.0887
MDL NO MFCD09971091
Pubchem ID 56972179.0
纯度 98%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件
粉末 -20°C 3年
液体 -80°C 1年
运输条件 Shipped in cold pack
别名

靶点

TargetActivity
IKKIC50 = 40 nM

参考文献

1Waelchli R, Bollbuck B, Bruns C, Buhl T, Eder J, Feifel R, Hersperger R, Janser P, Revesz L, Zerwes HG, Schlapbach A. Design and preparation of 2-benzamido-pyrimidines as inhibitors of IKK. Bioorg Med Chem Lett. 2006 Jan 1;16(1):108-12. doi: 10.1016/j.bmcl.2005.09.035
2Hermanson SB, Carlson CB, Riddle SM, Zhao J, Vogel KW, Nichols RJ, Bi K. Screening for novel LRRK2 inhibitors using a high-throughput TR-FRET cellular assay for LRRK2 Ser935 phosphorylation. PLoS One. 2012;7(8):e43580. doi: 10.1371/journal.pone.0043580

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