验证数据展示
产品信息
83347-6-RR targets IGFBP1 in ELISA applications and shows reactivity with Human samples.
| 经测试应用 | ELISA Application Description |
| 经测试反应性 | Human |
| 免疫原 | Fusion Protein 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | IGF binding protein 1 |
| 别名 | IGFBP1, IGFBP-1, IGFBP25, Insulin-like growth factor-binding protein 1, Placental protein 12, PP12, 240263B12, AFBP, hIGFBP 1, IBP 1, IBP1, IBP-1, IGF binding protein 1, IGF BP25, IGF-binding protein 1, IGFBP 1 |
| 计算分子量 | 28 kDa |
| GenBank蛋白编号 | NM_000596.4 |
| 基因名称 | IGFBP1 |
| Gene ID (NCBI) | 3484 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purfication |
| UNIPROT ID | P08833 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
IGF-binding proteins (IGFBPs) family contains members like IGFBP-1, -2, -3, -4,-5 and-6. IGFBPs prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. IGF-I physically interacts with IGFBP-1 and that IGFBP-1 also binds to an integrin receptor, but the effect of IGFBP-1 on cell migration may be independent of IGF-I and is probably mediated through the alpha 5 beta 1 integrin. Transgenic mice models demonstrated that IGFBPs played important roles in the pathogenesis of obesity and INS resistance. Studies conducted in humans demonstrated the close relation between IGFBPs and the components of the metabolic syndrome.