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验证数据展示

  • WB analysis using 21728-1-AP (same clone as 21728-1-PBS)

    WB analysis using 21728-1-AP (same clone as 21728-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 21728-1-AP (IDE antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 21728-1-PBS in a different storage buffer formulation.

  • IHC staining of human kidney using 21728-1-AP (same clone as 21728-1-PBS)

    IHC staining of human kidney using 21728-1-AP (same clone as 21728-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human kidney using 21728-1-AP (IDE antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 21728-1-PBS in a different storage buffer formulation.

  • IHC staining of human kidney using 21728-1-AP (same clone as 21728-1-PBS)

    IHC staining of human kidney using 21728-1-AP (same clone as 21728-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human kidney using 21728-1-AP (IDE antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 21728-1-PBS in a different storage buffer formulation.

  • IP experiment of HepG2 using 21728-1-AP (same clone as 21728-1-PBS)

    IP experiment of HepG2 using 21728-1-AP (same clone as 21728-1-PBS)

    IP result of anti-IDE (IP:21728-1-AP, 4ug; Detection:21728-1-AP 1:500) with HepG2 cells lysate 1600ug. This data was developed using the same antibody clone with 21728-1-PBS in a different storage buffer formulation.

  • WB analysis of HeLa using 21728-1-AP (same clone as 21728-1-PBS)

    WB analysis of HeLa using 21728-1-AP (same clone as 21728-1-PBS)

    WB result of IDE antibody (21728-1-AP; 1:400; incubated at room temperature for 1.5 hours) with sh-Control and sh-IDE transfected HeLa cells. This data was developed using the same antibody clone with 21728-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO验证

IDE Polyclonal antibody, PBS Only

IDE Polyclonal Antibody for WB, IHC, IP, Indirect ELISA
Cat No. 21728-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, IP, Indirect ELISA

别名

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

21728-1-PBS targets IDE in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, IP, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag16392

Product name: Recombinant human IDE protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 676-1019 aa of BC096336

Sequence: EQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 Abeta degrading protease
别名
计算分子量 1019 aa, 118 kDa
观测分子量 100-120 kDa
GenBank蛋白编号BC096336
基因名称 IDE
Gene ID (NCBI) 3416
RRIDAB_10804773
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDP14735
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

IDE (INS-degrading enzyme) belongs to the peptidase M16 family. It is also known as insulysin and is a 110-kD neutral metallopeptidase that can degrade a number of peptides, including INS and beta-amyloid(PMID:9830016). The reduction of IDE expression may be a risk factor for AD, and that IDE may interact with APOE status to affect beta-amyloid metabolism(PMID:12507914). It can exsit as a homodimer and form higher oligomers(PMID:17613531). This antibody is specific to IDE.

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