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I3MT-3

I3MT-3 (HMPSNE) 是一种有效的、具有细胞膜渗透性的、选择性的 3-巯基丙酮酸硫转移酶 (3MST)的抑制剂，IC50值为2.7 μM，对其他硫化氢/磺胺制硫酶没有活性。它靶向位于 3MST 活性位点的过硫半胱氨酸残基。

CAS号

459420-09-8

分子式

C17H14N2O2S

主要靶点

Hippo pathway

仅限科研使用

Cat No : CM02302

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Synonyms

HMPSNE

验证数据展示

  • CAS No.: 459420-09-8

    I3MT-3
    CAS#: 459420-09-8

产品信息

I3MT-3 (HMPSNE) is a potent, selective and cell membrane permeability inhibitor of 3-mercaptopyruvate sulfur transferase (3MST), which targets the persulfated cysteine residues located at the active site of 3MST.

CAS号 459420-09-8
分子式 C17H14N2O2S
主要靶点 Hippo pathway
主要通路 干细胞
分子量 310.4
纯度 99.86%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 HMPSNE

靶点活性

Hippo pathway:2.7 μM

体外活性

I3MT-3 shows a dose-dependent inhibition of 3-MST activity from CT26 homogenates, which contain the murine form of the enzyme. The IC50 of HMPSNE for murine 3-MST is calculated as 2.3 μM with a cozncentration-dependent decrease of AzMC fluorescence[1].I3MT-3 (0-300 μM; 48 hours) inhibits CT26 cells proliferate with increasing concentrations of I3MT-3. Confluence of cells treated with HMPSNE is recorded each hour for 48 h by the IncuCyte method[2].

溶解度

DMSO:120mg/mL (386.64mM)

参考文献

1.Hanaoka K, Sasakura K, Suwanai Y, et al. Discovery and Mechanistic Characterization of Selective Inhibitors of H2S-producing Enzyme: 3-Mercaptopyruvate Sulfurtransferase (3MST) Targeting Active-site Cysteine Persulfide. Sci Rep. 2017;7:40227. Published 2017 Jan 12. doi:10.1038/srep40227

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