• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

(-)-Huperzine A

CAS号

102518-79-6

分子式

C15H18N2O

主要靶点

AChR|AChE|iGluR|Apoptosis

仅限科研使用

Cat No : CM02636

Print datasheet

Synonyms

石杉碱|石杉碱甲|pain|non-cholinergic|neurodegenerative|neuropathic|neuroprotective|inhibit|Inhibitor|Ionotropic glutamate receptors|cognitive-enhancing|cholinergic|Cholinesterase (ChE)|()Huperzine A|( ) Huperzine A|AChE|AChE (G4 form)|Apoptosis|anti-cholinesterase|Alzheimer's|Huperzine A|HupA|iGluR|disease|diseases|effects

验证数据展示

  • CAS No.: 102518-79-6

    (-)-Huperzine A
    CAS#: 102518-79-6

产品信息

CAS号 102518-79-6
分子式 C15H18N2O
主要靶点 AChR|AChE|iGluR|Apoptosis
主要通路 凋亡|神经科学|神经科学|离子通道
分子量 242.32
纯度 99.87%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 石杉碱|石杉碱甲|pain|non-cholinergic|neurodegenerative|neuropathic|neuroprotective|inhibit|Inhibitor|Ionotropic glutamate receptors|cognitive-enhancing|cholinergic|Cholinesterase (ChE)|()Huperzine A|( ) Huperzine A|AChE|AChE (G4 form)|Apoptosis|anti-cholinesterase|Alzheimer's|Huperzine A|HupA|iGluR|disease|diseases|effects

靶点活性

AChE (G4 form):7 nM(Ki)

体内活性

与他克林,毒扁豆碱,加兰他敏和卡巴拉汀相比,(-)-Huperzine A在对AChE活性的抑制更强,但对BuChE的效果最差。(-)-Huperzine A使细胞免受谷氨酸盐、过氧化氢、β-淀粉样蛋白缺血和星形孢菌素诱导的细胞毒性及凋亡。(-)-Huperzine A通过调节凋亡蛋白Bcl-2、Bax、p53和caspase-3的表达,减轻氧化应激,保护线粒体,使神经生长因子及其受体上调及干扰淀粉样前体蛋白代谢等一系列过程实现上述保护作用。(-)-Huperzine A会优先抑制四聚体AChE（G4形式）。

体外活性

在动物模型和AD患者中,(-)-Huperzine A可改善学习和记忆障碍.大鼠处死30 min后,与对照组使用生理盐水相比,(-)-Huperzine A明显抑制皮质,纹状体,海马区,内延髓,侧隔核,小脑和丘脑中的AchE活性.

溶解度

DMSO:30 mg/mL (123.8 mM)

参考文献

1.Zhao Q, et al. Eur J Pharmacol, 2002, 455(2-3), 101-107.
2.Zhang HY, et al. Trends Pharmacol Sci, 2006, 27(12), 619-625.
3.Wang R, et al. Acta Pharmacol Sin, 2006, 27(1), 1-26.
4.Zheng CY, et al. J Neurosci Res, 2008, 86(11), 2432-2440.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
×
×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2