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Recombinant Human TMIGD2/CD28H protein (rFc Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg2264

Print datasheet

Synonyms

TMIGD2/CD28, TMIGD2/CD28H, CD28 homolog, CD28H, IGPR1

验证数据展示

  • Purity of Recombinant Human TMIGD2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human TMIGD2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Human TMIGD2 protein Leu23-Gly150 (Accession# Q96BF3-1) with a rabbit IgG Fc tag at the C-terminus.
基因ID 126259
蛋白编号 Q96BF3-1
预测分子量 40.3 kDa
SDS-PAGE 46-60 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Transmembrane and immunoglobulin domain-containing protein 2 (TMIGD2, also known as CD28H and IGPR1), plays a role in cell-cell interaction, migration, and angiogenesis. Through interaction with HHLA2, it costimulates T-cells in the context of TCR-mediated activation and enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade. TMIGD2 has been associated with several diseases, particularly in the context of cancer. It is aberrantly expressed by human AML cells and can be used to identify and enrich functional LSCs. The predicted molecular weight of the TMIGD2 protein is 31 kDa. The higher molecular weight of TMIGD2 could be associated with its potential glycosylation at its extracellular region.

参考文献:

1. Nader Rahimi, et al.(2012) Mol Biol Cell. 23(9):1646-56. 
2. Yuwen Zhu, et al.(2013) Nat Commun. 4:2043.
3. Hao Wang, et al,(2024) Nat Commun. 15(1):11
4. Nader Rahimi, et al. ( 2012) Mol Biol Cell. 23(9):1646-56