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Recombinant Human PLXNC1 protein (rFc Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg2721

Print datasheet

Synonyms

CD232, plexin C1, PLXN C1, VESPR

验证数据展示

  • Purity of Recombinant Human PLXNC1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

    Purity of Recombinant Human PLXNC1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Human PLXNC1 protein Ala35-Thr944 (Accession# O60486) with a rabbit IgG Fc tag at the C-terminus.
基因ID 10154
蛋白编号 O60486
预测分子量 126.2 kDa
SDS-PAGE 130-200 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

PLXNC1 (Plexin-C1)is asemaphorin receptorthat bridgesextracellular guidance cuestointracellular GTPase signaling, influencingcell adhesion, migration, and immune modulation. Predominantly expressed inneuronal, epithelial, and immune tissues, it regulatesaxon guidanceandinflammatory balanceviaSEMA7A-dependent pathways. Dysregulated PLXNC1 signaling contributes tocancer progression,immune dysregulation, andneuronal pathologies, highlighting its versatile role incell communication and morphogenesis.

参考文献:

1. Ni, Zhizhan et al. Frontiers in cell and developmental biology vol. 9 662707. 2 Jul. 2021, doi:10.3389/fcell.2021.662707
2. Bernard, Alice et al. Journal of biomedical science vol. 31,1 82. 21 Aug. 2024, doi:10.1186/s12929-024-01074-x
3. Fink, Steffen et al. Molecular vision vol. 18 (2012): 2229-40.
4. Yi, Jianfeng et al. Phytomedicine : international journal of phytotherapy and phytopharmacology vol. 135 (2024): 156137. doi:10.1016/j.phymed.2024.156137
5. Meng, Nan et al. Journal of orthopaedic surgery and research vol. 18,1 784. 18 Oct. 2023, doi:10.1186/s13018-023-04207-4
6. Chen, Jie et al. Frontiers in oncology vol. 10 33. 4 Feb. 2020, doi:10.3389/fonc.2020.00033
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