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Recombinant Human Neuropilin 2 protein (rFc Tag)(HPLC verified)

种属

Human

纯度

>90 %, SDS-PAGE
>90%, SEC-HPLC

标签

rFc Tag

生物活性

未测试

Cat no : Eg3125

Print datasheet

Synonyms

NRP2, Neuropilin-2

验证数据展示

  • Purity of Recombinant Human Neuropilin 2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

    Purity of Recombinant Human Neuropilin 2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

  • The purity of Human Neuropilin 2 was greater than 90% as determined by SEC-HPLC.

    The purity of Human Neuropilin 2 was greater than 90% as determined by SEC-HPLC.

产品信息

纯度 >90 %, SDS-PAGE
>90%, SEC-HPLC
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Human Neuropilin 2 protein Arg21-Pro864 (Accession# O60462-1) with a rabbit IgG Fc tag at the C-terminus.
基因ID 8828
蛋白编号 O60462-1
预测分子量 121.1 kDa
SDS-PAGE 120-140 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

NRP2 (Neuropilin-2) is a type I transmembrane glycoprotein belonging to the neuropilin family. It acts as a multifunctional receptor that binds to a variety of ligands, including vascular endothelial growth factor (VEGF) and signaling proteins (e.g., Sema3C and Sema3F), and plays important roles in neurodevelopment, angiogenesis, and immunomodulation. NRP2 is a cell surface molecule that is widely present in pancreatic cancer cells and is upregulated in various malignant tumors, such as hepatocellular carcinoma, gastric carcinoma, thyroid carcinoma and prostate cancer. It plays a crucial role in tumor cell growth, migration, invasion and angiogenesis, and monoclonal antibodies against NRP2 have been proposed as a potential strategy for pancreatic cancer treatment.

参考文献:

1. Zhao Z, et al. Adv Sci (Weinh). 2023;10(30):e2303872.                                          
2. Luo S, et al. FASEB J. 2022;36(2):e22079.                                                              
3. Kang Y, et al. Am J Transl Res. 2021;13(8):8938-8951.                                           
4. Schulz A, et al. Front Oncol. 2020;9:1461.                                                            
5. Luo X, et al. Cell Biosci. 2020;10:113.