• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

Recombinant Human NPRC/NPR3 protein (rFc Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg2988

Print datasheet

Synonyms

NPR3, ANP C, ANP-C, ANPR C, ANPRC

验证数据展示

  • Purity of Recombinant Human NPRC was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human NPRC was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Human NPRC protein Gly27-GLu481 (Accession# P17342-1) with a rabbit IgG Fc tag at the C-terminus.
基因ID 4883
蛋白编号 P17342-1
预测分子量 76.4 kDa
SDS-PAGE 76-85 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

NPR3 (Natriuretic Peptide Receptor 3) is a widely expressed natriuretic peptide receptor that mediates natriuretic peptide degradation and plays a role in the regulation of endochondral ossification and bone growth, as well as acting as a tumor suppressor or promoter in some types of cancers. NPR3 may function differently in different types of cancers, and the up-regulation of NPR3 upregulation of NPR3 promotes the proliferation of colorectal cancer cells, and knockdown promotes the metastasis of clear cell renal cell carcinoma. It has been suggested that NPR3 may act as a new tumor suppressor by blocking the PI3K/AKT pathway and is regulated by POU2F1 transcription.

参考文献:

1. Li S. et al. (2021) Cell Signal. 86:110074.                                                               
2. Devotta A. et al. (2023) Elife. 12:e84036.                                                                 
3. Dabaghie D. et al. (2024) Sci Rep. 14(1):11850.