Recombinant Human MICA protein (Myc Tag, His Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

Myc Tag, His Tag

生物活性

未测试

Cat no : Eg0181

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Synonyms

MIC A, MIC-A



产品信息

纯度 >90 %, SDS-PAGE
内毒素 <1.0 EU/μg protein, LAL method
生物活性
Not tested
来源 HEK293-derived Human MICA protein Glu24-Gln308 (Accession# BC016929) with a Myc tag and a His tag at the C-terminus.
基因ID 100507436
蛋白编号 BC016929
预测分子量 38.4 kDa
SDS-PAGE
组分 Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Human MHC class I chain-related genes located within the HLA class I region of chromosome 6 encode MHC class I chain-related A and B (MICA and MICB). MICA and MICB are stress-inducible surface molecules that are not associated with β2-microglobulin and do not present peptides. They are expressed in intestinal epithelium and many epithelial tumors. MICA and MICB are ligands for NKG2D which is an activating receptor that is expressed on most natural killer (NK) cells, CD8 αβ T cells, and γδ T cells.

参考文献:

1. Stephens, H A. Trends in immunology vol. 22,7 (2001): 378-85. 2. Groh, V et al. Science (New York, N.Y.) vol. 279,5357 (1998): 1737-40. 3. Groh, V et al. Proceedings of the National Academy of Sciences of the 4. United States of America vol. 96,12 (1999): 6879-84. 5. Bauer, S et al. Science (New York, N.Y.) vol. 285,5428 (1999): 727-9. 6. Steinle, A et al. Immunogenetics vol. 53,4 (2001): 279-87.