Recombinant Human MICA protein (Myc Tag, His Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
Myc Tag, His Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <1.0 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human MICA protein Glu24-Gln308 (Accession# BC016929) with a Myc tag and a His tag at the C-terminus. |
| 基因ID | 100507436 |
| 蛋白编号 | BC016929 |
| 预测分子量 | 38.4 kDa |
| SDS-PAGE | |
| 组分 | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Human MHC class I chain-related genes located within the HLA class I region of chromosome 6 encode MHC class I chain-related A and B (MICA and MICB). MICA and MICB are stress-inducible surface molecules that are not associated with β2-microglobulin and do not present peptides. They are expressed in intestinal epithelium and many epithelial tumors. MICA and MICB are ligands for NKG2D which is an activating receptor that is expressed on most natural killer (NK) cells, CD8 αβ T cells, and γδ T cells.
参考文献:
1. Stephens, H A. Trends in immunology vol. 22,7 (2001): 378-85. 2. Groh, V et al. Science (New York, N.Y.) vol. 279,5357 (1998): 1737-40. 3. Groh, V et al. Proceedings of the National Academy of Sciences of the 4. United States of America vol. 96,12 (1999): 6879-84. 5. Bauer, S et al. Science (New York, N.Y.) vol. 285,5428 (1999): 727-9. 6. Steinle, A et al. Immunogenetics vol. 53,4 (2001): 279-87.