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Recombinant Human IL-3RA/CD123 protein (rFc Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg2013

Print datasheet

Synonyms

IL3RA, CD123, hIL 3Ra, IL 3 receptor subunit alpha, IL 3R alpha

验证数据展示

  • Purity of Recombinant Human IL-3RA was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human IL-3RA was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Human IL-3RA protein Thr19-Arg305 (Accession# P26951-1) with a rabbit IgG Fc tag at the C-terminus.
基因ID 3563
蛋白编号 P26951-1
预测分子量 59.4 kDa
SDS-PAGE 68-85 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Interleukin-3 receptor subunit alpha (IL-3R alpha), also known as CD123, belongs to the cytokine receptor family. It is a glycoprotein containing an extracellular domain, involving a predicted Ig-like domain, two FnIII domains, a transmembrane domain and an intracellular domain. IL-3R alpha is expressed on hematopoietic progenitor cells, plasmacytoid dendritic cells, basophils, monocytes, some B cells, and in a variety of hematologic malignancies. IL-3 initially binds to IL-3R alpha and subsequently recruits the beta chain (CD131) to form the high-affinity receptor, resulting in the activation of a series of signaling pathways including the JAK/STAT, Ras-MAPK, and phosphatidylinositol 3-kinase pathways (PMID: 29296749). IL-3R signaling regulates the proliferation, survival, and differentiation of hematopoietic cells.

参考文献:

1. S Huang, et al. (1999). Stem Cells. 17(5):265-72.
2. Ugo Testa, et al. (2014). Biomark Res. 2(1):4.
3. Nicole L Wittwer, et al. (2017). Blood Adv. 1(15):1067-1079. 
4. Adam J Lamble, et al. (2022). J Clin Oncol. 40(3):252-261.