Recombinant Human IGFBP6 protein (Myc Tag, His Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
Myc Tag, His Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <1.0 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human IGFBP6 protein Arg28-Gly240 (Accession# P24592) with a Myc tag and a His tag at the C-terminus. |
| 基因ID | 3489 |
| 蛋白编号 | P24592 |
| 预测分子量 | 28.2 kDa |
| SDS-PAGE | |
| 组分 | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Insulin-like growth factor (IGF) binding protein (IGFBP6), a 240 amino acid protein, contains an IGFBP N-terminal domain and a thyroglobulin type-1 domain.It’s known for its identical protein binding activity and insulin-like growth factor II (IGF-II) binding activity. It plays a role in cell migration and positively regulates the stress-activated MAPK cascade. As a component of the insulin-like growth factor binary complex, IGFBP6 helps modulate the availability and activity of IGFs in the body. IGFBP6 has been implicated in obesity and serves as a biomarker for several conditions, including breast cancer, in situ carcinoma, leiomyoma, and neovascular inflammatory vitreoretinopathy. Research has shown that IGFBP6 can influence tumor progression and response to treatment in various cancer types, such as glioblastoma, ovarian cancer, and prostate cancer.
参考文献:
1.Liso, Arcangelo et al. International journal of molecular sciences vol. 23,8 (2022). 2.Piscazzi, Annamaria et al. Oncology letters vol. 23,6 (2022): 185. 3.Su, Meiming et al. Nature cardiovascular research vol. 4,2 (2025): 145-162.