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Recombinant Human HBEGF protein (rFc Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg3862

Print datasheet

Synonyms

Diphtheria toxin receptor, DT R, DTR, DTS, HB EGF

验证数据展示

  • Purity of Recombinant Human HBEGF was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) condition and stained using Coomassie blue.

    Purity of Recombinant Human HBEGF was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) condition and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Human HBEGF protein Leu20-Thr160 (Accession# Q99075) with a rabbit IgG Fc tag at the C-terminus.
基因ID 1839
蛋白编号 Q99075
预测分子量 42.0 kDa
SDS-PAGE 13-17 kDa & 42-54 kDa, reducing (R) condition
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

The epidermal growth factor (EGF) family member, heparin-binding EGF-like growth factor, (HBEGF), is present in the uterus at the time of embryo implantation, and its expression in trophoblast (TB) cells of the placenta indicate its central role in early implantation and subsequent placentation. HBEGF protects TB cells from apoptosis, and promotes their invasion. Transmembrane HBEGF cleavage in response to low O2 initiates autocrine signaling that increases HBEGF levels to a concentration that inhibits apoptosis. The autocrine upregulation of HBEGF requires activation of its cognate receptors (ERBB1 and ERBB4), and downstream signaling through any one of three MAPK pathways initiated by MAPK 1/3, MAPK14 or MAPK8.

参考文献:

1. Yoo, H J et al. Developmental genetics vol. 21,1 (1997): 102-8. 
2. Leach, R E et al. The Journal of clinical endocrinology and metabolism vol. 84,9 (1999): 3355-63. 
3. Armant, D Randall et al. Development (Cambridge, England) vol. 133,4 (2006): 751-9. 
4. Jain, Chandni V et al. PloS one vol. 11,10 (2016) e0163913. 
5. Jessmon, Philip et al. Biology of reproduction vol. 82,5 (2010): 921-9.