Recombinant Human CD244 protein (Myc Tag, His Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
Myc Tag, His Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <1.0 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human CD244 protein Cys22-Arg221 (Accession# Q9BZW8-2) with a Myc tag and a His tag at the C-terminus. |
| 基因ID | 51744 |
| 蛋白编号 | Q9BZW8-2 |
| 预测分子量 | 27.9 kDa |
| SDS-PAGE | |
| 组分 | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
CD244, also known as SLAMF4 or 2B4, is a type I transmembrane glycoprotein belonging to the signaling lymphocyte activation molecule (SLAM) family. It consists of an extracellular segment with two immunoglobulin (Ig)-like domains, a transmembrane region, and a cytoplasmic domain containing tyrosine-based motifs. CD244 is present on natural killer (NK) cells, γδ T cells, a subset of CD8+ T cells, monocytes, basophils, dendritic cells, and myeloid-derived suppressor cells (MDSCs). It binds to CD48 with high affinity and transmits stimulatory or inhibitory signals that regulate immune function.
参考文献:
1. Brown, M H et al. The Journal of experimental medicine vol. 188,11 (1998): 2083-90. 2. Agresta, Laura et al. Frontiers in immunology vol. 28,9 (2018) 2809. 3. Chlewicki, Lukasz K et al. Journal of immunology (Baltimore, Md. : 1950) vol. 180,12 (2008): 8159-67.