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Recombinant Human CD13 protein (rFc Tag)(HPLC verified)

种属

Human

纯度

>90 %, SDS-PAGE
>90%, SEC-HPLC

标签

rFc Tag

生物活性

未测试

Cat no : Eg3748

Print datasheet

Synonyms

Alanyl aminopeptidase, Aminopeptidase M, Aminopeptidase N, ANPEP, AP-M

验证数据展示

  • Purity of Recombinant Human CD13 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human CD13 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

  • The purity of Human CD13 was greater than 90% as determined by SEC-HPLC.

    The purity of Human CD13 was greater than 90% as determined by SEC-HPLC.

产品信息

纯度 >90 %, SDS-PAGE
>90%, SEC-HPLC
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Human CD13 protein Lys69-Lys967 (Accession# P15144) with a rabbit IgG Fc tag at the C-terminus.
基因ID 290
蛋白编号 P15144
预测分子量 129.0 kDa
SDS-PAGE 130-150 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

ANPEP (Aminopeptidase N) is a membrane-associated exonuclease, also known as CD13 or basic amino acid peptidase, that plays a role in glutathione metabolism and exhibits broad substrate specificity. The primary function of ANPEP is the N-terminal amino acid shearing of peptide chains, which participates in the degradation process of proteins, and is also implicated in the regulation of cell-surface antigen expression. ANPEP has been identified as a susceptibility gene for type 2 diabetes (T2D), but the mechanism by which it contributes to the development of the disease is not fully understood, and it has been suggested that it may be mediated through disruption of glutathione metabolism and redox homeostasis.

参考文献:

1. Kim JH,et al. Mol Cell Proteomics. 2022;21(11):100424.                                           
2. Korvyakova Y, et al. Gene. 2025;935:149050.