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Hck-IN-1

CAS号

1473404-51-1

分子式

C16H11ClN6O3S

主要靶点

Src|HIV Protease|Hck

仅限科研使用

Cat No : CM04596

Print datasheet

Synonyms

anti-retroviral|Asn126|diphenylpyrazolo|Human immunodeficiency virus|HIV Protease|HIV|HIVProtease|HIV-1 Nef|Hck|HckIN1|Hck-IN-1|Hck IN 1|Src|replication|Nef|Nef:Hck|Nef-dependent|Inhibitor|inhibit

验证数据展示

  • CAS No.: 1473404-51-1

    Hck-IN-1
    CAS#: 1473404-51-1

产品信息

CAS号 1473404-51-1
分子式 C16H11ClN6O3S
主要靶点 Src|HIV Protease|Hck
主要通路 微生物学|蛋白酶体|血管生成|蛋白酪氨酸激酶|蛋白酪氨酸激酶
分子量 402.81
纯度 99.07%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 anti-retroviral|Asn126|diphenylpyrazolo|Human immunodeficiency virus|HIV Protease|HIV|HIVProtease|HIV-1 Nef|Hck|HckIN1|Hck-IN-1|Hck IN 1|Src|replication|Nef|Nef:Hck|Nef-dependent|Inhibitor|inhibit

靶点活性

HIV-1 (Nef):100-300 nM

体外活性

Hck-IN-1能抑制所有十一种HIV-1 Nef嵌合体的复制（IC50：约300 nM于CEM-T4细胞中），显示出这种化合物对由各种HIV-1 Nef蛋白支持的HIV复制具有广泛的抑制作用。Hck-IN-1对体外其他Src家族成员的活性较弱，其IC50值均>20 μM，涵盖c-Src、Lck和Lyn。B9（1 μM；8天）在1.0 μM的浓度下完全抑制了Nef依赖的SFK激活。Hck-IN-1（0.1、0.3、1、3 μM）在记者细胞系TZM-bl中也以浓度依赖的方式抑制了Nef介导的HIV-1感染性增强。

溶解度

DMSO:12.5 mg/mL (31.03 mM)

参考文献

1.Emert-Sedlak LA, et al. Effector kinase coupling enables high-throughput screens for direct HIV-1 Nef antagonists with antiretroviral activity. Chem Biol. 2013 Jan 24;20(1):82-91.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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